1. Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation
- Author
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N. Torben Bech-Hansen, Kendra Potocki, Ford Burles, Sarah F. Barclay, and Giuseppe Iaria
- Subjects
Proband ,Apolipoprotein E ,Cognition disorders ,Short Communication ,genotype ,Population ,Biology ,050105 experimental psychology ,memory ,03 medical and health sciences ,0302 clinical medicine ,Genotype ,medicine ,0501 psychology and cognitive sciences ,Allele ,navigation ,education ,Allele frequency ,Genetics ,education.field_of_study ,spatial learning ,General Neuroscience ,05 social sciences ,Topographical disorientation ,Psychiatry and Mental health ,Clinical Psychology ,Cohort ,lipids (amino acids, peptides, and proteins) ,Geriatrics and Gerontology ,medicine.symptom ,030217 neurology & neurosurgery - Abstract
The three common alleles of the APOE gene, ɛ2/ɛ3/ɛ4, have been linked to human spatial orientation. We investigated the genetic role of APOE in developmental topographical disorientation (DTD), a lifelong condition that results in topographical disorientation. We genotyped the APOE ɛ2/ɛ3/ɛ4 alleles in a cohort of 20 unrelated DTD probands, and found allele frequencies not statistically different from the those seen in the population as a whole. Therefore, we found no evidence that DTD occurs preferentially on a genetic background containing any particular APOE allele, making it unlikely that these APOE alleles are contributing to the development of DTD.
- Published
- 2021