1. The Link between the Metabolic Syndrome and Cancer
- Author
-
Derek LeRoith, Sandra Braun, and Keren Bitton-Worms
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Inflammation ,Review ,Biology ,Bioinformatics ,Models, Biological ,Applied Microbiology and Biotechnology ,Risk Factors ,Neoplasms ,Internal medicine ,medicine ,Insulin ,cancer ,Obesity ,Insulin-Like Growth Factor I ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Dyslipidemias ,Metabolic Syndrome ,Incidence ,TOR Serine-Threonine Kinases ,Type 2 Diabetes Mellitus ,Cell Biology ,Hypoxia (medical) ,medicine.disease ,Receptor, Insulin ,Insulin-Like Growth Factor Binding Proteins ,Endocrinology ,medicine.symptom ,Signal transduction ,Metabolic syndrome ,Dyslipidemia ,Signal Transduction ,Developmental Biology - Abstract
Since the incidence of the metabolic syndrome is on the rise in the western world, its coherence to cancer is becoming more apparent. In this review we discuss the different potential factors involved in the increase of cancer in the metabolic syndrome including obesity, dyslipidemia and Type 2 Diabetes Mellitus (T2DM) as well as inflammation and hypoxia. We especially focus on the insulin and IGF systems with their intracellular signaling cascades mediated by different receptor subtypes, and suggest that they may play major roles in this process. Understanding the mechanisms involved will be helpful in developing potential therapeutics.
- Published
- 2011
- Full Text
- View/download PDF