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2. Prognostic and clinicopathological significance of Hapto and Gremlin1 expression in extrahepatic cholangiocarcinoma

Author

Zhulin Yang, Xiongying Miao, Daiqiang Li, Rushi Liu, Yuan Yuan, Zhengchun Wu, and Qiong Zou

Subjects
0301 basic medicine, medicine.medical_specialty, Adenoma, Gremlin1, Gastroenterology, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, extrahepatic cholangiocarcinoma, medicine, Hapto, Stage (cooking), Pathological, Survival analysis, business.industry, biliary tract adenoma, medicine.disease, stomatognathic diseases, Exact test, 030104 developmental biology, Oncology, Biliary tract, 030220 oncology & carcinogenesis, immunohistochemistry, Immunohistochemistry, business, Research Paper
Abstract

Background: Some studies have demonstrated that Hapto and Gremlin1 play an important biological role in many neoplasms. However, the role of Hapto and Gremlin1 in extrahepatic cholangiocarcinoma (ECC) remains to be revealed. Thus, this study investigated the prognostic and clinicopathological significance of Hapto and Gremlin1 expression in ECC. Methods: We examined Hapto and Gremlin1 expression in 100 ECC, 30 peritumoral tissues, 10 adenoma and 15 normal biliary tract tissues using EnVision immunohistochemistry. The relationship between Hapto and Gremlin 1 expression and clinicopathological parameters was evaluated using the χ2 test or Fisher's exact test. The overall survival of patients was analyzed using Kaplan-Meier univariate survival analysis and log-rank tests. Results: Hapto and Gremlin1 proteins were overexpressed in ECC compared to peritumoral tissues, adenoma, and normal biliary tract (P

Published
2020

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