1. [Effect of kardostin on the generative function of female rats].
- Author
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Lavrova EB, Kuzubova EA, Bugaeva LI, Petrov VI, Kheĭfets IA, Dugina IuL, and Épshteĭn OI
- Subjects
- Animals, Estrous Cycle drug effects, Female, Male, Menstrual Cycle drug effects, Nitric Oxide Synthase Type III antagonists & inhibitors, Nitric Oxide Synthase Type III metabolism, Pregnancy, Rats, Receptor, Angiotensin, Type 2 metabolism, Angiotensin II Type 2 Receptor Blockers pharmacology, Antibodies, Monoclonal pharmacology, Fertility drug effects, Fertilization drug effects, Sexual Behavior, Animal drug effects
- Abstract
The effects of kardostin on the ovulatory cycle, conception, and sexual behavior of female rats have been experimentally studied. It is established that a two-week therapy with kardostin at a dose of 5 and 15 mg/kg changed phases of the estrous cycle (with the estrus phase being most prevalent) and led to ambiguous changes in the sexual behavior of female rats (a dose of 5 mg/kg increased sexual behavior, while a dose of 15 mg/kg inhibited it), activated fertility, and improved the quality of conception.
- Published
- 2012