1. [Oxygenation state of brain in children upon reamberin infusion during post-anesthesia recovery].
- Author
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Lazarev VV, Khelimskaia IA, Tsypin LE, Mikhel'son VA, and Popova TG
- Subjects
- Adolescent, Anesthesia, Anesthesia Recovery Period, Anesthetics administration & dosage, Brain metabolism, Child, Child, Preschool, Drug Administration Schedule, Electron Transport Complex IV biosynthesis, Humans, Infant, Injections, Intravenous, Male, Meglumine administration & dosage, Meglumine therapeutic use, Neurons metabolism, Oxidation-Reduction, Oxyhemoglobins biosynthesis, Succinates therapeutic use, Succinic Acid chemistry, Brain drug effects, Meglumine analogs & derivatives, Neurons drug effects, Oxygen metabolism, Oxygen Consumption drug effects, Succinates administration & dosage
- Abstract
The effect of reamberin (1.5% solution of succinic acid and ion complex) on the oxygenation status of the brain was studied in children aged 1 - 14 years during recovery from anesthesia. It is established that reamberin in a dose of 2 ml/kg administered twice at the end of an operation increases the fraction of oxidized hemoglobin and cytochrome oxidase and enhances the regional saturation of brain tissue with oxygen, which is indicative of an increase in the potential of metabolism activation in neurons.
- Published
- 2012