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The process of purification of benzylpenicillin, penicillin V and erythromycin solutions with the use of semi-permeable membranes was studied. Practically complete separation of high-molecular admixtures and microbial colonies and separation of significant amounts of the colored compounds were shown to be possible. The purification process may be used effectively at the early stages of antibiotic production.

The separating capacity of a laboratory cup centrifuge and industrial centrifugal separator was compared. It was shown that the process of emulsion centrifugal separation could be modeled under laboratory conditions: antibiotic fermentation broth filtrate--organic solvent in industrial apparatus under similar conditions of preliminary mixing aqueous and organic phases.