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This investigation was conducted in three provinces of southern Vietnam in September-October 2011. A total of 257 small mammals of 11 species were caught; among them 120 rodents were infected with harvest mites of 8 species (Trom- biculidac). About 4000 mites of nearly 1200 identified species were collected from the small mammals. 17 species of harvest mites were identified. Walchia lupella, Leptotrombidium deliense, Walchia kritochaeta, and Walchia micropelta predominated in the collections. Most species of mites parasitized Rattus rattus (n= 15), Maxomys surifer (n=9), and B.savilei (n=7). The occurrence of Trombiculidaewas high on Bandicota savilei (90.0%), M.sunfer (87.8%), R.rattus (80.9%), and Bandicota indica (71.4%). The largest number of mites was observed in B.savilei and B.indica. The species of the genus Ascoschoengastia parasitized predominantly R.rattus and those of the genus Wachia did M.surifer. W.upella (n=7), L.delense (n=5), and Ascoschoengastiaindica (n=5) were associated with the widest range of nourishers. The species L.delicense known as a carrier of the causative agent of tsutsugamushi fever predominated in synanthropic rodents.

The effective application of GIS against parasitic diseases requires the patterns of spread of parasitic diseases in certain natural, climatic, and socioeconomic conditions of different regions where there are epidemically effective carriers. The epidemiological parameters defining a high risk of an epidemiological process after P.vivax importation into Russia were calculated using the developed HealthMapper controlled module with a database. Analysis of the average long-term air temperatures in the administrative territories of Russia over 78 years, namely July, the warmest month of the year when there are the largest numbers of all types of mosquito vectors and high levels of microfilaria in the peripheral blood of in- fected dogs (definitive hosts), has shown that the northern border of the maximum possible area of dirofilariasis in Russia is most fully described by the +14C July isotherm.

In 2010-2013, the quality of microscopic detection of the causative agents ofparasitic diseases in the feces has been assessed by the specialists of the laboratories of the therapeutic-and-prophylactic institutions (TPIs) and Hygiene and Epidemiology Centers, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, which are participants of the Federal System of External Quality Assessment of Clinical Laboratory Testing. Thirty-two specimens containing 16 species of human helminths and 4 species of enteric protozoa in different combinations were examined. The findings suggest that the quality of microscopic detection of the causative agents of parasitic diseases is low in the laboratories of health care facilities and that the specialists of the laboratories of TPIs and Hygiene and Epidemiology Centers, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, do not not possess the knowledge and skills necessary to make a laboratory diagnosis of helminths and enteric protozoa. The average detection rates of helminths and protozoa were at a level of 64 and 36%, respectively. The correct results showed that the proportion of helminths and protozoa were 94.5 and 5.5%, respectively. According to the biological and epidemiological classification of helminths, there were higher detection rates for contact group parasites (Enterobius vermicularis and Hymenolepis nana) and geohelminths (Ascaris, Trichuris trichiura, and others). Biohelminths (Opisthorchis, tapeworms, and others) Were detectable slightly worse.

The structure of a parasite system is formed and its functioning takes place in qualitatively different environments. The aquatic environment serves as a source of new elements and modules, energy, and information for parasite systems. And the parasite systems, for their part, affect the physical and biological parameters of the environment. Many intestinal infections caused by pathogenic microorganisms generally characterized by an acute disease course are related to a water factor. Such are typhus, typhoids, dysentery, cholera, salmonellosis, virus hepatitis, and others. Many parasitic diseases caused by pathogenic intestinal protistae (lambliasis, amebiasis, balantidiasis), blood parasite protistae (malaria), helminthes (opisthorchiasis, fascioliasis, diphyllobothriasis, cercariosis, pseudoamphistomosis) are also closely related to a water factor. Ascaridiasis, hymenolepiasis, trichocephalosis, and echinococcosis have a less close but still self-evident relationship to a water factor. The clbse relationships of many parasitic diseases to a water factor are also determined by the fact that the life cycles of many parasites necessarily include various intermediate hosts and parasite vectors, such as fishes, mollusks, crustaceans, and insects, which are aquatic organisms at some stages of their life. The results of continuous exposure of people to parasitic diseases are quite similar to the suppressive effects of the environment in the ecologically troublesome regions. The most prognostically useful information is formed while mapping by medical and ecological regions, by employing a combination of current mathematical and cartographical methods. The former include cluster analysis, quartering method, informational logical analysis, which are all described in this article and others. Regional mapping using the parasitological criteria should achieve at least two goals: 1) a scientific one that aids in finding causative connections and to prognosticate a situation; 2) a practical one that assists in developing regional programs for disease control and prevention. It is necessary to use the recommendations described in detail in the article in order to have the maximum results during medical and ecological mapping by the regions with a future goal of obtaining useful prognostic information.

A 15-year-old patient living in Bashkortostan was admitted as having a diagnosis of hydatid cyst of the left hepatic lobe for surgical treatment. He had the following concomitant diseases: neurodermatitis, bronchial asthma, and acute respiratory disease. After surgery (laparoscopic echinococcectomy), a portion was taken from the parent vesicle wall for a histological study. The parasite was detected on the inner membrane surface. It is suggested that this is a Pentastoma sp. (Arthropoda, Maxillopoda, Pentastomida, and Cephalobaenida). Thus, the observed patient has a combined hepatic invasion with Echinococcus and Pentastoma).

Data on a wide spread of parasitic diseases among Russia's population are presented in the article. The contamination of soil, water-reserves' surfaces, drinking water, foodstuffs and of household goods with helminth ovum and with cysts of intestinal pathogenic protozoa was shown to play the key role in the discussed process. Therefore, hygienic measures targeted at preservation, environmental sanitation and protection of the environment from causative agents of parasites that would reduce or expel the risk of new contaminations should be regarded as the key trend in preventing the parasitic diseases.

The ecological flexibility of parasitic systems is observed in parasites, such as pentastomas of Linguatula serrata and Armillifer sp., cestodes of Spirometra erinacei europaei, and dirofilariae of D. repens, D. immitis, D. ursi in relation to ecological shifts in the areas and anthropological pressure.

The materials are summarized on the basis of which the authors were given Diploma No. 118 (with priority from November 23, 1994, registered under No. 137) for discovery of the same name by the resolution of the International Association of Authors of Scientific Discoveries on May 12, 1999. FORMULA OF THE DISCOVERY: "The unknown hitherto regularity of formation of environmental parasitic contamination in urbanized ecosystems has been ascertained to embrace the following. In emergency of biosocial conditions leading to parameters: (structures, functions, regulatory mechanisms) transformations of evolutionary established parasitic systems owing to the development of expression, expansion and succession in protozoa and multicellular parasitic organisms' populations, the conditions arise that favour the violation of biocenoses homeostasis and changes in tension of epidemic, epizootic and epiphytotic processes during parasitoses". The discovery pertains to the field of biology in particular, to general, ecological, medical, veterinary and agricultural aspects of parasitology.

The paper gives a conceptual design of field parasitological studies of the association of the inoculation of the environment with the pathogens of parasitic diseases with their spread among humans. The design includes 6 stages that reflect their object, the problems to be solved, guidelines, and expected results. It is of great importance in defining a factorial (environmental) risk for infection with the causative agents of parasitoses and in substantiating and implementing measures to protect the environment from pollution and to prevent parasitic diseases in man and animals.

The paper provides the examination findings of helminthiases in the population of the town of Anadyr, the settlements of Kanchalan, Krasneno, and in the reindeer-breeding teams of the Anadyr District, CAD. The children infected with enterobiasis were shown to amount to 15.1 to 22.9%, diphyllobothriasis was detected in 12.9 - 33.7% of the examinees. Single cases of ascariasis were revealed. Analysis of 232 cases with echinococcosis demonstrates that the infection is prevalent over the whole Chukotka territory. Infection with Echinococcus multilocularis is more common in the indigenous population in the north-east of the District and that with Echinococcus granulosus in the central and northern regions. High extensive and intensive parasitic contamination rates of environmental objects, such as soil, sewage, household appliances, fish, etc., were noted, indicating a constant risk for Chukotka population's infection with parasites.

Studying parasitic contamination is regarded as an individual research trend for large-scale land and water areas whose natural habitat is greatly modified by man-made influences. On the one hand, parasitic contamination as its particular form acts as a factor that destabilizing the environment, on the other, the man-made deformation of natural biocenoses, which is induced by socioeconomic influences promote its occurrence and manifestations. The investigations of parasitic contamination are beyond the scope of the routine parasitological goals, though they involve their whole package and should be considered as an ecological objective of environmental protection. The cenotic communications of the links of the parasitic systems with the physicochemical and biological ingredients of the habitat predetermine qualitative and quantitative differences of parasitic contamination in the large urban areas and, finally, the dissimilar course of epidemiological, epizootic, and phytototic processes in parasitic diseases in their various sectors. The major factors influencing the levels of the parasitic pollution of the Moscow megalopolis were analyzed. These included various lines of economic activities, the population's living conditions, procedures for manufacturing foodstuffs, demographic changes. In the recent years, the situation in many parasitic infections in man (trichinosis, cryptobiasis, enterobiasis, toxocariasis, etc.), animals (fascioliasis, trichinosis, etc.) and plants (viral, fungal, and nematode diseases). There is an increase in the population of mosquitos, lice, fleas, and other insects which are vectors of dangerous parasitic diseases of man and animals.

Specific drugs, most of them heterocyclic compounds, are leading in the therapy of parasitic infections despite their relative toxicity and potent mutagenicity. In some parasitic diseases chemotherapy is of low efficacy (hydatid and multilocular echinococcosis, African trypanosomiasis) or practically absent (American trypanosomiasis) mostly due to suppression or distortion of an immune response. Methods of immunocorrection using recombinant cytokines (interleukins, interferons) or their inducers are to be borrowed from the practice of treatment of oncological, lymphoproliferative diseases and other immune deficiencies. For instance, alpha-interferon and gamma-interferon inducers should be used in echinococcosis, where, as our studies have shown, the production of these cytokines is markedly suppressed. The enforcement of chemotherapeutic effect by "parachemotherapy" (Sh. D. Moshkovskiĭ, 1944), the effect of nonspecific pharmacological drugs upon the cells and tissues damaged by parasites (like Ca2+ transport blockers in drug-resistant falciparum malaria), should be used, for instance, recombinant gamma-interferon plus specific drugs in toxoplasmosis. Modern methods of immunotherapy based on the molecular mechanisms of a host-parasite relationship should be created, for instance, monoclonal antibodies to C3 receptors of membranes of cells invaded with Toxoplasma gondii. Immunotoxins such as monoclonal antibodies to myoblast receptors conjugated to 5-nitroimidazolyl-thiadiazole in Chagas' disease should be tested. The above mentioned biological approaches should increase the efficacy of chemotherapy in parasitic diseases with smaller amounts of specific drugs and less courses of treatment.