1. Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial.
- Author
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Richardson BA, Lavreys L, Martin HL Jr, Stevens CE, Ngugi E, Mandaliya K, Bwayo J, Ndinya-Achola J, and Kreiss JK
- Subjects
- Administration, Intravaginal, Adolescent, Adult, Double-Blind Method, Erythema chemically induced, Female, Follow-Up Studies, Gels, Humans, Incidence, Kenya epidemiology, Middle Aged, Nonoxynol adverse effects, Sex Work statistics & numerical data, Sexually Transmitted Diseases diagnosis, Sexually Transmitted Diseases epidemiology, Sexually Transmitted Diseases microbiology, Surface-Active Agents adverse effects, Vaginal Creams, Foams, and Jellies, Vaginal Diseases chemically induced, Nonoxynol therapeutic use, Sexually Transmitted Diseases prevention & control, Surface-Active Agents therapeutic use
- Abstract
Background: Low-dose nonoxynol-9 products have a potential advantage of reduced toxicity. However, little is known about their efficacy in reducing the incidence of sexually transmitted diseases (STDs)., Goal: To determine the effect that an intravaginal gel containing 52.5 mg of nonoxynol-9 has on the acquisition of STDs in a cohort of HIV-1-seronegative female sex workers in Mombasa, Kenya., Study Design: A randomized double-blind placebo controlled trial was performed., Results: In this study, 139 women were randomized to the nonoxynol-9 group and 139 to the placebo group. No significant differences were found between the two study groups in terms of safety outcomes and reported symptoms, except for a lower incidence of vaginal erythema in the nonoxynol-9 group. There was a significantly higher incidence of gonorrhea in the nonoxynol-9 group than in the placebo group. No significant differences were observed between the groups for acquisition of Candida, trichomonas, bacterial vaginosis, C trachomatis, syphilis, or HIV-1, although the statistical power to detect differences for some of these STDs was limited., Conclusions: In this randomized placebo-controlled trial of a low-dose nonoxynol-9 gel, a significantly higher incidence of gonorrhea was found in the nonoxynol-9 group, but no significant differences between the groups were found for Candida, trichomonas, bacterial vaginosis, C trachomatis, syphilis, or HIV-1.
- Published
- 2001
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