1. [Shortened antimicrobial therapy duration].
- Author
-
Dinh A and Castan B
- Subjects
- Humans, Urinary Tract Infections drug therapy, Duration of Therapy, Drug Administration Schedule, Time Factors, Anti-Bacterial Agents therapeutic use, Bacterial Infections drug therapy
- Abstract
SHORTENED ANTIMICROBIAL THERAPY DURATION. Antibiotic treatment durations represent an important field of current clinical research. Indeed, shortening antibiotic duration during bacterial pathologies has several advantages: reducing the emergence of resistance on an individual and collective scale, reducing costs, adverse effects and the environmental impact. However, a rigorous investigation is necessary to properly assess the absence of impact on the individual prognosis. In recent years, several randomized trials have made it possible to validate short durations of antibiotic therapy for frequent bacterial pathologies: 5 days during simple acute pyelonephritis, 7 days for non-febrile urinary tract infections in men, 3 to 5 days during acute bacterial pneumonia, 6 weeks for pyogenic spondylodiscitis. However, some durations seem incompressible and/or require individualization: 14 days for febrile male urinary tract infections, 12 weeks for infections on osteoarticular prostheses. It is necessary to reduce the duration of antibiotic treatment to the minimum necessary and to evaluate personalized durations taking into account, in particular, immunocompromised patients who are often excluded from trials., Competing Interests: A. Dinh déclare avoir participé à des interventions ponctuelles pour Shionogi, MSD, Sanofi, Pfizer, Menarini et avoir été pris en charge à l’occasion de déplacement pour congrès, par Shionogi, MSD, Sanofi, Pfizer, Menarini. B. Castan déclare avoir participé à des interventions ponctuelles pour Sanofi-Aventis, MSD, Shionogi, Advanz Pharma, Eumedica et avoir été pris en charge, à l’occasion de déplacements pour congrès, par MSD et Advanz Pharma.
- Published
- 2024