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This publication presents the results of studying the biosafety of microorganisms used for the development of a biological product-a litter destructor, both individually and in a joint composition. In the experiment, the culture of Stylonychia (Stylonychia mytilus) and laboratory animals (rabbits, mice, and rats) were used. Based on a series of preclinical studies, it was found that the studied microorganisms individually do not indicate any symptoms of virulence, toxigenicity, toxicity and do not give an affirmative counteraction to the formation of hemolysin. The results of the express method showed that the aqueous and acetone extracts obtained from the joint microbial composition did not have a detrimental effect on the culture of protozoa, the viability in all groups was 100.0%. The analysis of the dermonecrotic effect of the studied microbial preparation demonstrated that the studied extracts did not cause hemorrhage, hyperemia, peeling, edema, and other pathology indicating an inflammatory process on the skin of laboratory rabbits. Conducting an acute experiment confirmed the safety of the studied microbial consortium, since during the research the laboratory mice remained active, mobile, no signs of poisoning or other pathology were found, and the conducted pathoanatomical autopsy did not reveal lesions of the parenchymal organs of the laboratory test objects. In general, the results of the studies indicated that the investigated cultures of microorganisms and their joint composition in the composition of the biological product-destructor do not show a toxic impact on the body of lab test objects, which confirms their harmlessness. [ABSTRACT FROM AUTHOR]

Today, a small number of full-fledged multifunctional CT systems are used for planning intraoperative intervention using mixed reality, for example, in cardiovascular surgery and urology, especially in Oncology. Surgeons today need a wide field of view to operate. Currently, the use of technologies like the DaVinci robot surgeon is constrained by the bulkiness of software and hardware solutions, the lack of trained specialists, and the high cost of equipment. There is no technology for navigating the course of the operation, with a layer of mixed reality being applied to the patient during the operation, so that the surgeon can use it to track the position of the organ, organ systems, and surgical instruments in real-time. The developed software prototype allows you to create three-dimensional models of internal organs based on computer and magnetic resonance imaging images with the possibility of simulating surgical intervention. Augmented reality glasses are also used to practice the skills of operations on a virtual patient using phantom dummies, linking surgical instruments to holography, as well as fully combining the simulation of the preoperative period with a real patient in real-time. [ABSTRACT FROM AUTHOR]