10 results on '"Matsui, Daisuke"'
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2. Association Between PSCA Variants and Duodenal Ulcer Risk
- Author
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Usui, Yoshiaki, Matsuo, Keitaro, Oze, Isao, Ugai, Tomotaka, Koyanagi, Yuriko, Maeda, Yoshinobu, Ito, Hidemi, Hishida, Asahi, Takeuchi, Kenji, Tamura, Takashi, Tsukamoto, Mineko, Kadomatsu, Yuka, Hara, Megumi, Nishida, Yuichiro, Shimoshikiryo, Ippei, Takezaki, Toshiro, Ozaki, Etsuko, Matsui, Daisuke, Watanabe, Isao, Suzuki, Sadao, Watanabe, Miki, Nakagawa-Senda, Hiroko, Mikami, Haruo, Nakamura, Yohko, Arisawa, Kokichi, Uemura, Hirokazu, Kuriki, Kiyonori, Takashima, Naoyuki, Kadota, Aya, Ikezaki, Hiroaki, Murata, Masayuki, Nakatochi, Masahiro, Momozawa, Yukihide, Kubo, Michiaki, and Wakai, Kenji
- Subjects
Adult ,Genetic Markers ,Male ,Genotype ,GPI-Linked Proteins ,Polymorphism, Single Nucleotide ,Helicobacter Infections ,Cohort Studies ,Antigens, Neoplasm ,Risk Factors ,Genetics ,Humans ,cross-sectional study ,Genetic Predisposition to Disease ,lcsh:R5-920 ,Helicobacter pylori ,DNA, Neoplasm ,Middle Aged ,psca ,japan ,Neoplasm Proteins ,Gene Expression Regulation, Neoplastic ,Cross-Sectional Studies ,Immunoglobulin G ,Original Article ,Female ,duodenal ulcer ,lcsh:Medicine (General) - Abstract
Background: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population. Methods: Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU. Results: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18–1.51; P = 2.28 × 10−6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs. Conclusions: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
- Published
- 2021
3. Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study
- Author
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Fujii, Ryosuke, Hishida, Asahi, Nishiyama, Takeshi, Nakatochi, Masahiro, Matsuo, Keitaro, Ito, Hidemi, Nishida, Yuichiro, Shimanoe, Chisato, Nakamura, Yasuyuki, Turin, Tanvir Chowdhury, Suzuki, Sadao, Watanabe, Miki, Ibusuki, Rie, Takezaki, Toshiro, Mikami, Haruo, Nakamura, Yohko, Ikezaki, Hiroaki, Murata, Masayuki, Kuriki, Kiyonori, Kuriyama, Nagato, Matsui, Daisuke, Arisawa, Kokichi, Katsuura-Kamano, Sakurako, Tsukamoto, Mineko, Tamura, Takashi, Kubo, Yoko, Kondo, Takaaki, Momozawa, Yukihide, Kubo, Michiaki, Takeuchi, Kenji, Wakai, Kenji, Fujii, Ryosuke, Hishida, Asahi, Nishiyama, Takeshi, Nakatochi, Masahiro, Matsuo, Keitaro, Ito, Hidemi, Nishida, Yuichiro, Shimanoe, Chisato, Nakamura, Yasuyuki, Turin, Tanvir Chowdhury, Suzuki, Sadao, Watanabe, Miki, Ibusuki, Rie, Takezaki, Toshiro, Mikami, Haruo, Nakamura, Yohko, Ikezaki, Hiroaki, Murata, Masayuki, Kuriki, Kiyonori, Kuriyama, Nagato, Matsui, Daisuke, Arisawa, Kokichi, Katsuura-Kamano, Sakurako, Tsukamoto, Mineko, Tamura, Takashi, Kubo, Yoko, Kondo, Takaaki, Momozawa, Yukihide, Kubo, Michiaki, Takeuchi, Kenji, and Wakai, Kenji
- Abstract
Background: Inflammation is thought to be a risk factor for kidney disease. However, whether inflammatory status is either a cause or an outcome of chronic kidney disease remains controversial. We aimed to investigate the causal relationship between high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) using Mendelian randomization (MR) approaches. Methods: A total of 10,521 participants of the Japan Multi-institutional Collaborative Cohort Study was analyzed in this study. We used two-sample MR approaches (the inverse-variance weighted (IVW), the weighted median (WM), and the MR-Egger method) to estimate the effect of genetically determined hs-CRP on kidney function. We selected four and three hs-CRP associated single nucleotide polymorphisms (SNPs) as two instrumental variables (IV): IVCRP and IVAsian, based on SNPs previously identified in European and Asian populations. IVCRP and IVAsian explained 3.4% and 3.9% of the variation in hs-CRP, respectively. Results: Using the IVCRP, genetically determined hs-CRP was not significantly associated with eGFR in the IVW and the WM methods (estimate per 1 unit increase in ln(hs-CRP), 0.000; 95% confidence interval [CI], −0.019 to 0.020 and −0.003; 95% CI, −0.019 to 0.014, respectively). For IVAsian, we found similar results using the IVW and the WM methods (estimate, 0.005; 95% CI, −0.020 to 0.010 and −0.004; 95% CI, −0.020 to 0.012, respectively). The MR-Egger method also showed no causal relationships between hs-CRP and eGFR (IVCRP: −0.008; 95% CI, −0.058 to 0.042; IVAsian: 0.001; 95% CI, −0.036 to 0.036). Conclusion: Our two-sample MR analyses with different IVs did not support a causal effect of hs-CRP on eGFR.
- Published
- 2022
4. Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer
- Author
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Usui, Yoshiaki, Matsuo, Keitaro, Oze, Isao, Ugai, Tomotaka, Koyanagi, Yuriko, Maeda, Yoshinobu, Ito, Hidemi, Hishida, Asahi, Takeuchi, Kenji, Tamura, Takashi, Tsukamoto, Mineko, Kadomatsu, Yuka, Hara, Megumi, Nishida, Yuichiro, Shimoshikiryo, Ippei, Takezaki, Toshiro, Ozaki, Etsuko, Matsui, Daisuke, Watanabe, Isao, Suzuki, Sadao, Watanabe, Miki, Nakagawa-Senda, Hiroko, Mikami, Haruo, Nakamura, Yohko, Arisawa, Kokichi, Uemura, Hirokazu, Kuriki, Kiyonori, Takashima, Naoyuki, Kadota, Aya, Ikezaki, Hiroaki, Murata, Masayuki, Nakatochi, Masahiro, Momozawa, Yukihide, Kubo, Michiaki, Wakai, Kenji, Usui, Yoshiaki, Matsuo, Keitaro, Oze, Isao, Ugai, Tomotaka, Koyanagi, Yuriko, Maeda, Yoshinobu, Ito, Hidemi, Hishida, Asahi, Takeuchi, Kenji, Tamura, Takashi, Tsukamoto, Mineko, Kadomatsu, Yuka, Hara, Megumi, Nishida, Yuichiro, Shimoshikiryo, Ippei, Takezaki, Toshiro, Ozaki, Etsuko, Matsui, Daisuke, Watanabe, Isao, Suzuki, Sadao, Watanabe, Miki, Nakagawa-Senda, Hiroko, Mikami, Haruo, Nakamura, Yohko, Arisawa, Kokichi, Uemura, Hirokazu, Kuriki, Kiyonori, Takashima, Naoyuki, Kadota, Aya, Ikezaki, Hiroaki, Murata, Masayuki, Nakatochi, Masahiro, Momozawa, Yukihide, Kubo, Michiaki, and Wakai, Kenji
- Abstract
Background: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population. Methods: Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU. Results: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18–1.51; P = 2.28 × 10−6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs. Conclusions: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
- Published
- 2021
5. Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer
- Author
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Usui, Yoshiaki, primary, Matsuo, Keitaro, additional, Oze, Isao, additional, Ugai, Tomotaka, additional, Koyanagi, Yuriko, additional, Maeda, Yoshinobu, additional, Ito, Hidemi, additional, Hishida, Asahi, additional, Takeuchi, Kenji, additional, Tamura, Takashi, additional, Tsukamoto, Mineko, additional, Kadomatsu, Yuka, additional, Hara, Megumi, additional, Nishida, Yuichiro, additional, Shimoshikiryo, Ippei, additional, Takezaki, Toshiro, additional, Ozaki, Etsuko, additional, Matsui, Daisuke, additional, Watanabe, Isao, additional, Suzuki, Sadao, additional, Watanabe, Miki, additional, Nakagawa-Senda, Hiroko, additional, Mikami, Haruo, additional, Nakamura, Yohko, additional, Arisawa, Kokichi, additional, Uemura, Hirokazu, additional, Kuriki, Kiyonori, additional, Takashima, Naoyuki, additional, Kadota, Aya, additional, Ikezaki, Hiroaki, additional, Murata, Masayuki, additional, Nakatochi, Masahiro, additional, Momozawa, Yukihide, additional, Kubo, Michiaki, additional, and Wakai, Kenji, additional
- Published
- 2021
- Full Text
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6. Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study
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Hara, Megumi, primary, Nishida, Yuichiro, additional, Tanaka, Keitaro, additional, Shimanoe, Chisato, additional, Koga, Kayoko, additional, Furukawa, Takuma, additional, Higaki, Yasuki, additional, Shinchi, Koichi, additional, Ikezaki, Hiroaki, additional, Murata, Masayuki, additional, Takeuchi, Kenji, additional, Tamura, Takashi, additional, Hishida, Asahi, additional, Tsukamoto, Mineko, additional, Kadomatsu, Yuka, additional, Matsuo, Keitaro, additional, Oze, Isao, additional, Mikami, Haruo, additional, Kusakabe, Miho, additional, Takezaki, Toshiro, additional, Ibusuki, Rie, additional, Suzuki, Sadao, additional, Nakagawa-Senda, Hiroko, additional, Matsui, Daisuke, additional, Koyama, Teruhide, additional, Kuriki, Kiyonori, additional, Takashima, Naoyuki, additional, Nakamura, Yasuyuki, additional, Arisawa, Kokichi, additional, Katsuura-Kamano, Sakurako, additional, and Wakai, Kenji, additional
- Published
- 2021
- Full Text
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7. Associations Between hOGG1 Ser326Cys Polymorphism and Increased Body Mass Index and Fasting Glucose Level in the Japanese General Population
- Author
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Hara, Megumi, primary, Nakamura, Kazuyo, additional, Nanri, Hinako, additional, Nishida, Yuichiro, additional, Hishida, Asahi, additional, Kawai, Sayo, additional, Hamajima, Nobuyuki, additional, Kita, Yoshikuni, additional, Suzuki, Sadao, additional, Mantjoro, Eva Mariane, additional, Ohnaka, Keizo, additional, Uemura, Hirokazu, additional, Matsui, Daisuke, additional, Oze, Isao, additional, Mikami, Haruo, additional, Kubo, Michiaki, additional, and Tanaka, Hideo, additional
- Published
- 2014
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8. Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study
- Author
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Wakai, Kenji, primary, Hamajima, Nobuyuki, additional, Okada, Rieko, additional, Naito, Mariko, additional, Morita, Emi, additional, Hishida, Asahi, additional, Kawai, Sayo, additional, Nishio, Kazuko, additional, Yin, Guang, additional, Asai, Yatami, additional, Matsuo, Keitaro, additional, Hosono, Satoyo, additional, Ito, Hidemi, additional, Watanabe, Miki, additional, Kawase, Takakazu, additional, Suzuki, Takeshi, additional, Tajima, Kazuo, additional, Tanaka, Keitaro, additional, Higaki, Yasuki, additional, Hara, Megumi, additional, Imaizumi, Takeshi, additional, Taguchi, Naoto, additional, Nakamura, Kazuyo, additional, Nanri, Hinako, additional, Sakamoto, Tatsuhiko, additional, Horita, Mikako, additional, Shinchi, Koichi, additional, Kita, Yoshikuni, additional, Turin, Tanvir Chowdhury, additional, Rumana, Nahid, additional, Matsui, Kenji, additional, Miura, Katsuyuki, additional, Ueshima, Hirotsugu, additional, Takashima, Naoyuki, additional, Nakamura, Yasuyuki, additional, Suzuki, Sadao, additional, Ando, Ryosuke, additional, Hosono, Akihiro, additional, Imaeda, Nahomi, additional, Shibata, Kiyoshi, additional, Goto, Chiho, additional, Hattori, Nami, additional, Fukatsu, Mitsuru, additional, Yamada, Tamaki, additional, Tokudome, Shinkan, additional, Takezaki, Toshiro, additional, Niimura, Hideshi, additional, Hirasada, Kazuyo, additional, Nakamura, Akihiko, additional, Tatebo, Masaya, additional, Ogawa, Shin, additional, Tsunematsu, Noriko, additional, Chiba, Shirabe, additional, Mikami, Haruo, additional, Kono, Suminori, additional, Ohnaka, Keizo, additional, Takayanagi, Ryoichi, additional, Watanabe, Yoshiyuki, additional, Ozaki, Etsuko, additional, Shigeta, Masako, additional, Kuriyama, Nagato, additional, Yoshikawa, Aya, additional, Matsui, Daisuke, additional, Watanabe, Isao, additional, Inoue, Kaoru, additional, Ozasa, Kotaro, additional, Mitani, Satoko, additional, Arisawa, Kokichi, additional, Uemura, Hirokazu, additional, Hiyoshi, Mineyoshi, additional, Takami, Hidenobu, additional, Yamaguchi, Miwa, additional, Nakamoto, Mariko, additional, Takeda, Hideo, additional, Kubo, Michiaki, additional, and Tanaka, Hideo, additional
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- 2011
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9. GWAS of Folate Metabolism With Gene-environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese: The J-MICC Study.
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Tsukamoto M, Hishida A, Tamura T, Nagayoshi M, Okada R, Kubo Y, Kato Y, Hamajima N, Nishida Y, Shimanoe C, Ibusuki R, Shibuya K, Takashima N, Nakamura Y, Kusakabe M, Nakamura Y, Koyanagi YN, Oze I, Nishiyama T, Suzuki S, Watanabe I, Matsui D, Otonari J, Ikezaki H, Katsuura-Kamano S, Arisawa K, Kuriki K, Nakatochi M, Momozawa Y, Takeuchi K, Wakai K, and Matsuo K
- Subjects
- Humans, Japan, Male, Female, Middle Aged, Adult, Aged, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Vitamin B 12 blood, Cohort Studies, Polymorphism, Single Nucleotide, East Asian People, Folic Acid blood, Genome-Wide Association Study, Gene-Environment Interaction, Homocysteine blood, Life Style
- Abstract
Background: The present genome-wide association study (GWAS) aimed to reveal the genetic loci associated with folate metabolites, as well as to detect related gene-environment interactions in Japanese., Methods: We conducted the GWAS of plasma homocysteine (Hcy), folic acid (FA), and vitamin B
12 (VB12 ) levels in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study participants who joined from 2005 to 2012, and also estimated gene-environment interactions. In the replication phase, we used data from the Yakumo Study conducted in 2009. In the discovery phase, data of 2,263 participants from four independent study sites of the J-MICC Study were analyzed. In the replication phase, data of 573 participants from the Yakumo Study were analyzed., Results: For Hcy, MTHFR locus on chr 1, NOX4 on chr 11, CHMP1A on chr 16, and DPEP1 on chr 16 reached genome-wide significance (P < 5 × 10-8 ). MTHFR also associated with FA, and FUT2 on chr 19 associated with VB12 . We investigated gene-environment interactions in both studies and found significant interactions between MTHFR C677T and ever drinking, current drinking, and physical activity >33% on Hcy (β = 0.039, 0.038 and -0.054, P = 0.018, 0.021 and <0.001, respectively) and the interaction of MTHFR C677T with ever drinking on FA (β = 0.033, P = 0.048)., Conclusion: The present GWAS revealed the folate metabolism-associated genetic loci and gene-environment interactions with drinking and physical activity in Japanese, suggesting the possibility of future personalized cardiovascular disease prevention.- Published
- 2024
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10. Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study.
- Author
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Hara M, Nishida Y, Tanaka K, Shimanoe C, Koga K, Furukawa T, Higaki Y, Shinchi K, Ikezaki H, Murata M, Takeuchi K, Tamura T, Hishida A, Tsukamoto M, Kadomatsu Y, Matsuo K, Oze I, Mikami H, Kusakabe M, Takezaki T, Ibusuki R, Suzuki S, Nakagawa-Senda H, Matsui D, Koyama T, Kuriki K, Takashima N, Nakamura Y, Arisawa K, Katsuura-Kamano S, and Wakai K
- Subjects
- Humans, Male, Cohort Studies, Cross-Sectional Studies, Japan epidemiology, Female, Adult, Middle Aged, Aged, Glomerular Filtration Rate physiology, Risk Factors, Exercise physiology, Renal Insufficiency, Chronic epidemiology, Renal Insufficiency, Chronic prevention & control, Sedentary Behavior
- Abstract
Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function., Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m
2 . Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied., Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P for trend MVPA <0.0001) and lower eGFR (P for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68-0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52-2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD., Conclusion: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.- Published
- 2023
- Full Text
- View/download PDF
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