Search

金ナノ粒子は, 生体に対する毒性が低く, 生体親和性を確保しやすい特徴をもっている。金ナノ粒子は単独では不安定なため, 安定性を確保するために生体親和性および癌細胞指向性の高いチオールポルフィリン化合物を設計・合成し, 金ナノ粒子の修飾を試みた。両者を結合させた化合物に電磁波を照射した場合, 発熱することが予測され, 有効な抗癌活性が期待できると考えた。ポルフィリン修飾型金ナノ粒子の粒子径制御では, 水素化ホウ素ナトリウム還元法およびクエン酸還元法を用い, 安定なポルフィリン修飾型金ナノ粒子を構築した。UV-visスペクトルおよび蛍光スペクトルを測定した結果, ポルフィリン修飾型金ナノ粒子の構築を確認した。また, 安定性の確認として, DLS測定を用いた擬似血中滞留試験を行った。誘電率測定により金ナノ粒子の発熱量を算出し, 調製したポルフィリン修飾型金ナノ粒子が温熱療法などにおいて有効な活性が期待できることが示唆された。

Aluminosilicate mesoporous materials (AIMS) were synthesized by two different methods. In "stepwise direct synthesis" of AIMS, sodium aluminate was added at the second ageing after the first ageing of sodium silicate and surfactant mixtures with the purpose of Al incorporation on or near the surface region of the pore wall in order to provide easily accessible ion-exchange sites. Most of the Al atoms in the AIMS prepared by the "stepwise direct synthesis" were present as tetrahedral-coordinated framework in the resulting mesostructured aluminosilicate of hexagonal symmetry. FT-IR spectra of pyridine adsorbed on the AIMS revealed that the AIMS prepared by the "stepwise direct synthesis" had a higher ratio of Bronsted acid sites to Lewis acid sites than the AIMS prepared by the conventional direct synthesis. Copper ion-exchanged AIMS (Cu/AlMS) catalysts were evaluated for NO reduction by CO. The Cu/AlMS catalyst prepared by the "stepwise direct synthesis" demonstrated catalytic activity for NO reduction without an aggregation of Cu species.

Zirconium--containing mesoporous silicas, Zr-MCM-41, were synthesized by two different methods. They were characterized by XRD, TEM, nitrogen adsorption and EXAFS and applied to the reaction for the peroxidative bromination of phenol red. In one method, we prepared Zr-MCM-41 by hydrolysis and condensation for the mixture of tetraethoxysilane (TEOS) and zirconium tetra-n-propoxide (ZTNP) in aqueous cetyltrimetylammonium bromide solution. EXAFS analysis revealed that zirconium species in this Zr-MCM-41 aggregated each other and formed the bonds of Zr-O-Zr. This catalyst had a low catalytic activity for the peroxidative bromination of phenol red. In the other method, ethanolic zirconium chloride solution and pure silica MCM-41 were used for impregnation. Zirconium species in this Zr-MCM-41 were highly dispersed as shown in the result of EXAFS analysis. This catalyst exhibited a high catalytic activity for the peroxidative bromination of phenol red. Zirconium species aggregated each other by calcination at 573 K, which caused reduction of catalytic activity.