1. In vivo bioresorbability and bone formation ability of sintered highly pure calcium carbonate granules
- Author
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Toshitake Furusawa, Shota Umemoto, Tohru Sekino, Masahiko Tajika, and Hidero Unuma
- Subjects
Calcite ,Materials science ,Aragonite ,technology, industry, and agriculture ,chemistry.chemical_element ,Sintering ,Calcium ,engineering.material ,equipment and supplies ,Phosphate ,Resorption ,chemistry.chemical_compound ,Calcium carbonate ,chemistry ,Chemical engineering ,In vivo ,Ceramics and Composites ,engineering ,General Dentistry - Abstract
Calcium carbonate-based bone substitutes derived from natural coral exoskeleton (aragonite) are resorbed and remodeled faster than calcium phosphate-based substitutes. However, coral species with structures appropriate for use as bone substitutes are very limited. Therefore, it is important to evaluate potential of artificial calcium carbonate ceramics as a bone substitute. In this study, calcium carbonate granules with various porosities and pore sizes were prepared by sintering a highly pure (>99.98%) calcium carbonate powder (calcite), and their resorption properties and bone formation abilities were examined in vivo for the first time. The sintered calcium carbonate was resorbed faster than β-tricalcium phosphate, which has a similar structure. However, sintered calcium carbonate did not promote new bone formation during long-term implantation. Furthermore, both resorption and new bone formation were affected by the pore structure. The optimal structures of the artificially sintered calcium carbonate bone substitute were also discussed.
- Published
- 2021
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