1. Renal Cell Carcinoma with Skull Base Metastasis Preceded by Paraneoplastic Signs in a Chronic Hemodialysis Patient
- Author
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Kazunori Endo, Shigeki Yamada, Yutaka Kuroda, Kaoru Tabei, and Ryo Okano
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Paraneoplastic Syndromes ,medicine.medical_treatment ,Autopsy ,Skull Base Neoplasms ,Skull Base Neoplasm ,Renal Dialysis ,Renal cell carcinoma ,Internal Medicine ,medicine ,Carcinoma ,Humans ,Carcinoma, Renal Cell ,Cystic kidney ,Kidney ,business.industry ,General Medicine ,Kidney Diseases, Cystic ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,medicine.anatomical_structure ,Chronic Disease ,Hemodialysis ,Tomography, X-Ray Computed ,business ,Kidney disease - Abstract
A 59-year-old man who had received chronic hemodialysis developed left occipital pain and hypoglossal nerve palsy. He was diagnosed as having skull base metastasis from renal cell carcinoma related to acquired cystic kidney. Retrospective analysis revealed the patient had had elevated serum C-reactive protein and alkaline phosphatase levels before the symptoms appeared. Radiotherapy to the skull base relieved the pain. Finally he died with generalized metastases. Serum interleukin-6 levels measured during admission had been elevated, and interleukin-6 mRNA was detected in the autopsy specimen of renal cell carcinoma. Interleukin-6 might be involved in the etiology of paraneoplastic signs.
- Published
- 2001
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