1. Aggressive Inflammatory Myofibroblastic Tumor without Anaplastic Lymphoma Kinase Gene Rearrangement in the Rectum with Liver Metastasis
- Author
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Noboru Watanabe, Reina Ohba, Kae Sugawara, Shigeto Koizumi, Sho Fukuda, Hiroshi Nanjo, Tamotsu Matsuhashi, Yosuke Shimodaira, Yuko Hiroshima, Yusato Suzuki, and Katsunori Iijima
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Lymphoma ,Prednisolone ,Anti-Inflammatory Agents ,Rectum ,Case Report ,030204 cardiovascular system & hematology ,Metastasis ,Lesion ,03 medical and health sciences ,Fatal Outcome ,0302 clinical medicine ,Biopsy ,Internal Medicine ,medicine ,Humans ,rectum ,Neoplasm Metastasis ,Aged, 80 and over ,IgG4 ,medicine.diagnostic_test ,Rectal Neoplasms ,business.industry ,Anaplastic Lymphoma Kinase Gene Rearrangement ,Liver Neoplasms ,Soft tissue ,Histology ,General Medicine ,medicine.disease ,liver metastasis ,medicine.anatomical_structure ,ALK ,inflammatory myofibroblastic tumor ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,medicine.drug - Abstract
Inflammatory myofibroblastic tumor is a rare intermediate-grade tumor. We herein report the case of an 81-year-old man with rectal ulceration and abnormal retroperitoneal soft tissue with a high serum level of IgG4. The administration of prednisolone reduced the retroperitoneal lesion; however, the rectal ulceration expanded. Surgical resection was performed. A histopathological examination revealed proliferating spindle cells accompanied by inflammatory cells and plasma cells. Liver metastasis emerged two months after surgical resection, and the histology of the proliferating spindle cells sampled by a fine-needle biopsy was similar to that of the rectal tissue. The patient ultimately died of inflammatory myofibroblastic tumor.
- Published
- 2020