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Your search keyword '"Toshiyuki, Kitano"' showing total 3 results
Start Over Author "Toshiyuki, Kitano" Publisher japanese society of internal medicine
3 results on '"Toshiyuki, Kitano"'

1. Recurrent Epstein-Barr Virus-positive (EBV+) Primary Central Nervous System Lymphoma (PCNSL) in a Patient with Clinical Features of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)

Author

Akio Ikeda, Akifumi Takaori-Kondo, Naoki Goda, Takashi Ayaki, Toshiyuki Kitano, Momoko Nishikori, Ryosuke Takahashi, Masahiro Nagano, Natsuko Koita, and Sachiko Minamiguchi

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Herpesvirus 4, Human, recurrence, Lymphoma, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS), Case Report, Antineoplastic Agents, 030204 cardiovascular system & hematology, Methylprednisolone, Central Nervous System Neoplasms, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Biopsy, Internal Medicine, medicine, repeat brain biopsy, Brain Stem Neoplasms, Humans, Brain magnetic resonance imaging, Lymphocytes, primary central nervous system lymphoma (PCNSL), Inflammation, medicine.diagnostic_test, Chronic lymphocytic inflammation, business.industry, Brain biopsy, Primary central nervous system lymphoma, Epstein-Barr Virus Positive, General Medicine, medicine.disease, repeat brain biopsy, Epstein-Barr virus (EBV), Epstein-Barr virus (EBV), Treatment Outcome, Chronic Disease, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, business
Abstract

Primary central nervous system lymphoma (PCNSL) and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) can share clinical features and may be indistinguishable, even after brain biopsy. We encountered a case of Epstein-Barr virus-positive (EBV+) PCNSL recurrence in a patient with clinical features of CLIPPERS, and repeat brain biopsy was required to reach the correct diagnosis. Four years after the initial diagnosis and treatment of PCNSL, "peppering" punctate enhanced lesions with transient steroid responsiveness were detected during brain magnetic resonance imaging (MRI). A second brain biopsy supported a diagnosis of CLIPPERS, while a third biopsy confirmed the diagnosis of recurrent PCNSL.

Published
2019

2. A rare case of adult autoimmune neutropenia successfully treated with prednisolone

Author

Hiroshi Kawabata, Mari Fujita, Akifumi Takaori-Kondo, Tadakazu Kondo, Kimiko Yurugi, Tomomi Oka, Hideyo Hirai, Kohei Yamashita, Toshiyuki Kitano, Taira Maekawa, and Masakatsu Hishizawa

Subjects
medicine.medical_specialty, Neutropenia, Neutrophils, Prednisolone, Case Report, 030204 cardiovascular system & hematology, Granulocyte, Gastroenterology, Autoimmune Diseases, 03 medical and health sciences, Leukocyte Count, 0302 clinical medicine, Internal medicine, Granulocyte Colony-Stimulating Factor, Internal Medicine, medicine, Humans, Autoantibodies, granulocyte-colony-stimulating factor, business.industry, Autoantibody, food and beverages, General Medicine, Middle Aged, medicine.disease, human neutrophil antigen, Discontinuation, Granulocyte colony-stimulating factor, autoimmune neutropenia, medicine.anatomical_structure, Autoimmune neutropenia, Immunology, Absolute neutrophil count, Female, business, 030215 immunology, medicine.drug, Granulocytes
Abstract

Autoimmune neutropenia (AIN) is a rare disorder that may cause life-threatening infections. In adults, most cases are secondary to other pathological conditions, and primary AIN is extremely rare. We herein report a case involving a 57-year-old woman diagnosed with AIN. A granulocyte immunofluorescence test detected autoantibodies against human neutrophil antigens in her serum, while various examinations revealed no other causes of neutropenia, suggesting her AIN was primary. She was refractory to granulocyte-colony-stimulating factor but responded to prednisolone. Her neutrophil count remained normal after gradual discontinuation of prednisolone. Diagnostic procedures and optimal treatments for this disorder need to be established.

Published
2017

3. A Case of Follicular Lymphoma Associated with Paraneoplastic Cerebellar Degeneration

Author

Akifumi Takaori-Kondo, Masafumi Ihara, Ryosuke Takahashi, Takayuki Ishikawa, Tadakazu Kondo, Momoko Nishikori, Hirofumi Matsuyama, Yuichiro Hashi, Masakatsu Hishizawa, Yayoi Shimazu, Sonoyo Yoshida, Toshiyuki Kitano, and Eiko N. Minakawa

Subjects
Male, Pathology, medicine.medical_specialty, medicine.medical_treatment, Follicular lymphoma, Malignancy, Paraneoplastic Cerebellar Degeneration, Antibodies, Monoclonal, Murine-Derived, Antigens, Neoplasm, Antineoplastic Combined Chemotherapy Protocols, Internal Medicine, medicine, Humans, Cyclophosphamide, Lymphoma, Follicular, Chemotherapy, Cerebellar ataxia, business.industry, Remission Induction, Receptors, Interleukin-2, General Medicine, Middle Aged, Paraneoplastic cerebellar degeneration, medicine.disease, Lymphoma, nervous system, Doxorubicin, Vincristine, Prednisone, Rituximab, medicine.symptom, Complication, business, medicine.drug
Abstract

Paraneoplastic neurological disorders (PND) are neurological effects of malignancy that are recognized as immune-mediated disorders caused by aberrant expression of a tumor antigen that is normally expressed in the nervous system. We report a case of cerebellar ataxia which turned out to be paraneoplastic cerebellar degeneration, a subtype of PND that develops cerebellar symptoms, that was caused by follicular lymphoma. After chemotherapy, the patient attained sufficient improvement of cerebellar symptoms along with complete remission of lymphoma. Paraneoplastic cerebellar degeneration should be recognized as a rare complication of lymphoma as it is important to start proper treatment before the neurological symptoms become irreversible.

Published
2012
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