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Thirty-three joints in 31 patients of Kienböck disease were evaluated with three-phase bone scintigraphy. Follow-up studies were performed in 19 cases of them. The patients with increased ulnar blood flow on arterial phase and ample perfusion on venous phase in angiograms showed good clinical prognosis. This ample ulnar blood flow and perfusion might be essential for the recovery of this disease. Although staging was possible using static images alone, blood pool images provided more information about the present condition of lesions, such as hyperemic state and remodeling reactions. Blood pool image was indispensable for staging and analyzing lesions and evaluating post-operative course. Increased lunate perfusion in venous phase of angiograms and localized lunate uptake in blood pool images were the favorable signs, which were shown in most cases with good prognosis. It is concluded that three-phase bone scintigraphy gives useful informations for evaluating Kienböck disease which can not be obtained by conventional bone scintigraphy.

201Tl myocardial SPECT findings in infantile ventricular tachycardia (VT) were examined. The subjects were 4 cases of infantile VT subjected exercise-loading 201Tl scintigraphy in 1990. These cases (3 males and 1 female) were aged 11-14 years, being persistent and non-persistent type VT (2 cases each). Echocardiography revealed no abnormal findings in these 4 cases. Exercise-loading was performed by means of sitting ergometer. ECG revealed sinus arrhythmia except for one case which throughout its course of treatment, had already been presenting ventricular extrasystole from before the exercise-loading. Myocardial SPECT revealed persistent defects (anteroseptal wall defects in three case). The above suggests that 201Tl myocardial SPECT enables us to search for etiology of VT, prognosis and the like.

67Ga scintigraphy was performed in 865 patients, and in 1078 examinations. 67Ga accumulation was evaluated retrospectively for asymmetric accumulation in the shoulders. Approximately 50% of patients showed no asymmetric distribution of 67Ga in the shoulders. About 40% of patients showed increased accumulation in the right side and about 10% of patients showed increased accumulation in the left side. A change of 67Ga distribution in the shoulder joints was recognized in about 30% of patients during the follow-up study. Reasons for asymmetric distribution of 67Ga in the shoulders were considered to be due to bone metastasis, changes of local blood flow, edema, irradiation, muscle atrophy after cerebral paralysis, and operation. 67Ga scintigraphy showed a broader range and more prominent accumulation in the soft tissues around the shoulder joint than 99mTc-MDP scintigraphy. The accumulation of 99mTc-MDP was recognized to be in the center of the region of 67Ga accumulation. 99mTc-MDP scintigraphy showed more prominently increased accumulation than 67Ga scintigraphy in patients with osseous lesions. Similar factors appeared to have had an influence on the abnormal accumulation of 67Ga and 99mTc-MDP around the shoulder joint.

During the past 4 years, three-phase bone scintigraphy using 99mTc-MDP has been studied in 68 patients suffering from hemi-lateral hip-joint disorders. We were impressed on abnormal uptake of the shaft of femur on the involved side. 99mTc-MDP uptake in the shaft of femur is compared with between involved leg and normal leg of 68 cases with hemi-lateral hip-joint disorders (76 examinations). We excluded cases of osteomyelitis, cases of malignant tumor, and post-operative cases. In early images, the 99mTc-MDP uptake is not always increased in involved side. But in delayed images, there are no patients whose normal side's 99mTc-MDP uptake is increased. The 99mTc-MDP uptake in early image is not related only with blood flow of the thigh but with the amount of soft tissue of the thigh. And the 99mTc-MDP uptake in delayed image is related with disuse osteoporosis.

Thallium-201 myocardial single photon emission computed tomography (myocardial SPECT) has been believed likely to miss lesions or false lesions in the inferior wall of the left ventricle and septum in the vicinity of the basis of the heart. In 35 patients having undergone both coronary arterio-angiography and contrast left ventriculography, technetium-99m cardiac pool SPECT synchronized with electrocardiography (cardiac pool SPECT) and myocardial SPECT were performed simultaneously. Both cinematographic and phase techniques were used for the cardiac pool SPECT. Visual and Bull's eye techniques were used for the myocardial SPECT. The rate of correct diagnoses made by myocardial SPECT was compared by site with that by cardiac pool SPECT. With the inferior wall of the left ventricle of diagnoses made by cinematographic and phase techniques of cardiac pool SPECT, 97.0% each was correct. The rates of accurate diagnoses made by visual and Bull's eye techniques of myocardial SPECT were 97.0 and 93.9%, respectively. The rate at which at least one of the SPECT methods was correct was 97.1%. With the septum, the corresponding rates of accurate diagnoses were 97.1, 94.3, 90.0, and 90.9%, with rate of 94.3% at least one of these two methods made correct diagnoses. In conclusion, for diagnosing infarcts of the septal wall of the basis, the cardiac pool SPECT is more accurate than myocardial SPECT.

During the past 3 years and 6 months, serial 67Ga-citrate scintigraphy have studied in 113 patients. 22 patients of these showed absent liver uptake. All cases had malignant tumors. 41% in malignant lymphoma and 20% in lung cancer showed absent liver uptake scintigraphy in their progress. This ratio is more frequent than reported ratio. There was significant relationship between therapy with antineoplastic agents and absent or increased liver uptake scintigraphy. 4 cases, treated by irradiation, showed absent liver uptake scintigraphy. In 3 cases, elevated liver uptake, one was administered renal toxic agent and all were given 5-FU. Mild change of accumulation in liver may be beyond reported ratio. 67Ga-citrate scintigraphy is repeatedly used in course of malignant patients. We must know given agents and past history of treatment when 67Ga scintigraphy is evaluated.