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Carcinosarcoma is an extremely rare tumor of the breast comprising of two distinct cell lines i.e. the epithelial and mesenchymal. It is a highly aggressive tumor with a poor prognosis compared to other breast cancers with a reported incidence of less than 1% of all the breast cancers. A 35 year old female presented to surgical outpatient with a fungating mass in the right breast where cytological analysis from the affected areas revealed spindle cells of malignant potential. A modified radical mastectomy was performed and following histopathological examination of the excised tissue, a final diagnosis of carcinosarcoma of breast was concluded. Immunological staining done showed a negative staining for PR and positive staining for ER, Her-2/neu and CK receptors, as against the conventional triple negative staining pattern. Along with a rare staining pattern of this rare tumor reported in literature, this case merits presentation owing to its diagnostic and therapeutic challenges.

Epidermolysis Bullosa Simplex (EBS) has been subclassified into various subtypes on the basis of clinical features and histopathology predominantly into three divisions: Simplex, Junctional and Dystrophic. EBS is characterised by inter-epidermal blistering with minor internal engrossment. It’s always inherited in an autosomal dominant fashion and is also the least severe type of EB. More recently a recessive form of EBS has been described. The Koebner type of EBS (EBS-K), also known as the non-dowling meara or more recently the other generalised form, is usually presented at birth and is one of the rare presentations of EBS. Though always present with an extensive family history EBS-K is very rarely associated with de novo mutation.

Peutz-Jeghers syndrome is inherited as an autosomal dominant disorder presenting as hamartomatous polyps in small bowel with mucocutaneous pigmentation. We here present a case of 14 years old male presenting with symptoms of intestinal obstruction and mucocutaneous pigmentation along with family history of similar rashes, in both his mother and brother.