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Primary large cell neuroendocrine carcinoma of cervix is rare and very aggressive disease. There have been only few reported cases in literature. Here, we report a case of primary large cell neuroendocrine carcinoma of uterine cervix, staged Ib2, initially diagnosed as adenocarcinoma with neuroendocrine differentiation. Patient treated with radical hysterectomy and adjuvant radiotherapy and chemotherapy. The patient developed distant metastasis to brain without any other evidence of metastasis and local recurrence.