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Background: Antibiotic resistance in healthcare system is a widespread and inevitable problem which is mainly due to their inappropriate and indiscriminate prescribing or use. The misuse of antibiotics which is having substantial detrimental consequences is under the influence of clinicians’ education, existing beliefs, incentives offered by the pharmaceutical manufacturers, hospital’s sales profit and usual trend among the prescribers to use antimicrobials haphazardly. Objectives: The objective of the study was to determine the pattern of bacterial culture sensitivity and antimicrobials prescribing. Material and Methods: The study was a retrospective cross-sectional analysis of culture sensitivity reports for duration of 5 months (May to September 2010) at the laboratory of department of microbiology, Nobel Medical College and Research Centre, Biratnagar Nepal. Data was collected through a self designed and pre-piloted questionnaire. The questionnaire contained information on patient’s particulars, diagnosis, specimen, culture sensitivity and antimicrobials prescribed before performing culture sensitivity tests. Patient’s names and hospital Identification number were noted from the register and their respective prescriptions were investigated from medical record department of the hospital. The prescriptions were analyzed for the antimicrobials prescribed before carrying out culture sensitivity tests. The data was coded, verified, entered and analyzed using Statistical Package for Social Sciences version 11.5 Chicago, Inc. Results: Majority (71%) of the patients were below the age of 30 years. Diagnosis of the disease was not mentioned in majority (88%) of the reports. Staphylococcus aureus and Escherichia coli were the most commonly occurring bacteria (78%). Treating infectious complications with single antimicrobial agent was predominant (68%). Furthermore, third generation cephalosporins (47%) particularly ceftriaxone and cefotaxime were the most commonly prescribed agents, but culture sensitivity was not performed against them. There was a striking practice of prescribing antimicrobials against the bacteria which were either resistant or culture sensitivity was not performed. Conclusion: Bacterial resistance and inappropriate prescribing of antimicrobials are important issues at Nobel teaching hospital which entails expanding antimicrobial susceptibility testing to commonly used or prescribed antimicrobials