1. Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic review and meta‐analysis
- Author
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Remco de Bree, Marielle E.P. Philippens, Sanam Assili, Frans Kauw, Jan Willem Dankbaar, and Hilde J. G. Smits
- Subjects
medicine.medical_specialty ,Clinical Review ,recurrence ,laryngeal carcinoma ,Anterior commissure ,030218 nuclear medicine & medical imaging ,Hypopharyngeal Carcinoma ,Clinical Reviews ,03 medical and health sciences ,0302 clinical medicine ,Posterior commissure ,medicine ,magnetic resonance imaging ,Humans ,Neoplasm Staging ,Hypopharyngeal Neoplasms ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Arytenoid cartilage ,computed tomography ,Chemoradiotherapy ,medicine.anatomical_structure ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Relative risk ,Meta-analysis ,Radiology ,prognosis ,Larynx ,business - Abstract
Background In this systematic review, we aim to identify prognostic imaging variables of recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy. Methods A systematic search was performed in PubMed and EMBASE (1990–2020). The crude data and effect estimates were extracted for each imaging variable. The level of evidence of each variable was assessed and pooled risk ratios (RRs) were calculated. Results Twenty‐two articles were included in this review, 17 on computed tomography (CT) and 5 on magnetic resonance imaging (MRI) variables. We found strong evidence for the prognostic value of tumor volume at various cut‐off points (pooled RRs ranging from 2.09 to 3.03). Anterior commissure involvement (pooled RR 2.19), posterior commissure involvement (pooled RR 2.44), subglottic extension (pooled RR 2.25), and arytenoid cartilage extension (pooled RR 2.10) were also strong prognostic factors. Conclusion Pretreatment tumor volume and involvement of several subsites are prognostic factors for recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy.
- Published
- 2021