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The consumption of nutritional supplements by the population that practices physical activities in a regular, organized manner represents a form of scientific interest for professionals interested in analyzing the somatic and biological changes that occur under the influence of the stimuli provided by nutritional supplements. In this context, based on a new statistical model proposed by the authors, we aimed at assessing nutritional supplement consumption efficiency and the effects felt by the consumers in relation to both the achievement of their health goals and the destructuring of the biological processes following the consumption of these supplements. The new model, created by the authors, can be applied to the population of any other state in the world. The methods used in this article are analytical and prospective, and they are based on a qualitative questionnaire applied to 310 Romanian people who practice sports regularly; the sample group being considered representative for the entire population of Romania by the Cochran W.G. test. The results of the study are useful to both the specialists and the people who take nutritional supplements, and they help in improving the perception regarding the efficiency of these products on various categories, as will be seen from the data provided in this study. Moreover, the results of this analysis are also interesting for the providers of products such as pharmacies and authorized distributors, which can scientifically quantify their supply in the market., Competing Interests: This work was supported by the project “Excellence and involvement in intelligent development, research and innovation at ‘Dunarea de Jos’ University of Galati”, “DINAMIC”, financed by the Romanian Ministry of Research and Innovation in the framework of Programme 1 – Development of the national research and development system, Sub‐programme 1.2 – Institutional Performance – Projects for financing excellence in Research, Development and Innovation, Contract no. 12PFE/2021.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article., (© 2022 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)