1. Influence of Duodenal-Jejunal Implantation on Glucose Dynamics: A Pilot Study Using Different Nonlinear Methods
- Author
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Tricia Adjei, David Cuesta-Frau, Martin Haluzik, Daniel Novák, P Kaválková, Vaclav Burda, Daniel Abásolo, Milos Mraz, Manuel Varela, Borja Vargas, and Marek Benes
- Subjects
Multidisciplinary ,General Computer Science ,Article Subject ,Nonlinear methods ,Gastric bypass ,Nonlinear algorithms ,030209 endocrinology & metabolism ,medicine.disease ,lcsh:QA75.5-76.95 ,Sample entropy ,ARQUITECTURA Y TECNOLOGIA DE COMPUTADORES ,03 medical and health sciences ,0302 clinical medicine ,Weight loss ,Diabetes mellitus ,Statistics ,medicine ,030211 gastroenterology & hepatology ,lcsh:Electronic computers. Computer science ,Permutation entropy ,medicine.symptom ,Glucose dynamics ,Mathematics - Abstract
[EN] Diabetes is a disease of great and rising prevalence, with the obesity epidemic being a significant contributing risk factor. Duodenal¿jejunal bypass liner (DJBL) is a reversible implant that mimics the effects of more aggressive surgical procedures, such as gastric bypass, to induce weight loss. We hypothesized that DJBL also influences the glucose dynamics in type II diabetes, based on the induced changes already demonstrated in other physiological characteristics and parameters. In order to assess the validity of this assumption, we conducted a quantitative analysis based on several nonlinear algorithms (Lempel¿Ziv Complexity, Sample Entropy, Permutation Entropy, and modified Permutation Entropy), well suited to the characterization of biomedical time series. We applied them to glucose records drawn from two extreme cases available of DJBL implantation: before and after 10 months. The results confirmed the hypothesis and an accuracy of 86.4% was achieved with modified Permutation Entropy. Other metrics also yielded significant classification accuracy results, all above 70%, provided a suitable parameter configuration was chosen. With the Leave¿One¿Out method, the results were very similar, between 72% and 82% classification accuracy. There was also a decrease in entropy of glycaemia records during the time interval studied. These findings provide a solid foundation to assess how glucose metabolism may be influenced by DJBL implantation and opens a new line of research in this field., The Czech clinical partners were supported by DRO IKEM 000023001 and RVO VFN 64165. The Czech technical partners were supported by Research Centre for Informatics grant numbers CZ.02.1.01/0.0/16 - 019/0000765 and SGS16/231/OHK3/3T/13-Support of interactive approaches to biomedical data acquisition and processing. No funding was received to support this research work by the Spanish and British partners
- Published
- 2019