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Studies on feral cat diet offer important ecological information and are the first step towards determining their impact upon endangered species. However, in comparing seasonal changes in diet with seasonal prey availability, the scarce amount of research into oceanic islands worldwide must be considered when deciding if a specific population is actually affected by cat predation. Cat diet was analysed on Santa Luzia (Cabo Verde Islands) since this invasive predator is considered one of the main threats to native endangered species that require conservation measures. These previous studies were carried out in different seasons, providing contrasting results, skinks being more preyed upon in the rainy season and mice in the driest periods. To check these different results, we focussed on how cat diet varied seasonally in response to changes in prey abundance. Saurians were the most important prey group, followed by mice, invertebrates and birds. No seasonal differences were, however, observed in the different prey groups consumed, saurians being the main prey in both seasons. All cases reflected their respective abundances. Results corroborate the generalist and opportunistic trophic ecology of feral cats, providing important information to assess their impact on prey populations and design future eradication programmes., The Critical Ecosystems Partnership Fund (CEPF) provided funding to the Sociedade Portuguesa para o Estudo das Aves (SPEA), Biosfera 1, and the Royal Society for the Protection of Birds (RSPB) to undertake a project aimed at protecting threatened and endemic species in Cabo Verde. Direcção Nacional de Ambiente of the Cabo Verde Government authorised and supported the work on the islands. The manuscript was edited by Guido Jones, currently funded by the Cabildo de Tenerife, Canary Islands, under the TFinnova Programme supported by MEDI and FDCAN funds.