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2 results on '"Sundquist E"'

1. Extracellular interleukin‐17F has a protective effect in oral tongue squamous cell carcinoma

Author

Almahmoudi, R. (Rabeia), Salem, A. (Abdelhakim), Sieviläinen, M. (Meri), Sundquist, E. (Elias), Almangush, A. (Alhadi), Toppila-Salmi, S. (Sanna), Paavonen, T. (Timo), Salo, T. (Tuula), Al-Samadi, A. (Ahmed), Almahmoudi, R. (Rabeia), Salem, A. (Abdelhakim), Sieviläinen, M. (Meri), Sundquist, E. (Elias), Almangush, A. (Alhadi), Toppila-Salmi, S. (Sanna), Paavonen, T. (Timo), Salo, T. (Tuula), and Al-Samadi, A. (Ahmed)

Abstract

Background: Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin‐17F (IL‐17F) plays a protective role in many tumors. However, IL‐17F expression in oral tongue SCC tissue has not been investigated. Methods: Immunostaining of 83 oral tongue SCC specimens and blinded‐scoring were used to map IL‐17F expression, location, and distribution. Survival curves were constructed according to Kaplan‐Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses. Results: Mast cells are the major source of IL‐17F in oral tongue SCC. In multivariate analysis, only the extracellular mast cell‐derived IL‐17F at the tumor invasion front was associated with better disease‐specific survival in patients with all‐stages and early‐stages of oral tongue SCC. Conclusion: Extracellular mast cell‐derived IL‐17F is antitumorigenic in oral tongue SCC. It separates patients with early‐stage disease who are at high risk from patients who are at low risk. Furthermore, when analyzing tentative prognostic molecules, we conclude that in addition to the staining intensity, attention must be paid to the cellular source, distribution, and location of the molecule.

Published
2018

2. Clinicopathologic significance of ROCK2 expression in oral squamous cell carcinomas

Author

Dourado, M. R. (Mauricio R.), Oliveira, C. E. (Carine E. de), Sawazaki-Calone, I. (Iris), Sundquist, E. (Elias), Coletta, R. D. (Ricardo D.), and Salo, T. (Tuula)

Subjects
oral squamous cell carcinoma, Rho-associated coiled- coil kinase 2, prognosis, cancer-associated fibroblasts
Abstract

Background: Rho-associated coiled-coil kinase 2 (ROCK2) is an oncoprotein that controls cytoskeleton organization and acts as prognostic marker in different types of solid tumors. ROCK2 overexpression is also observed in cancer-associated fibroblasts (CAF), which suggests its relevance within the tumor microenvironment. This study aimed to access the prognostic value of ROCK2 in oral squamous cell carcinomas (OSCCs) and its association with CAF density. Methods: Rho-associated coiled-coil kinase 2 immunohistochemical analysis was applied in 93 OSCC samples from 2 centers in Brazil and Finland. The samples were also stained for isoform α of smooth muscle actin (α-SMA) to characterize the presence of CAF in the tumor stroma. Clinicopathological associations were analyzed using Chi-squared test, survival curves were constructed according to the Kaplan-Meier method, and Cox proportional hazard model was applied for multivariate survival analysis. Results: Advanced clinical stage (P = .002) and increased density of CAF (P = .002) were significantly associated with high ROCK2 expression. The high expression of ROCK2 was also associated with shortened disease-specific survival (HR: 2.22, 95% CI: 1.15–4.38, P = .04), but the association did not withstand the Cox multivariate survival analysis. Conclusions: The findings suggest that high ROCK2 expression in OSCC is associated with advanced disease and follows the increase in CAF density, which may be important for tumor progression.

Published
2017

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