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China is the country with the largest elderly population in the world. Age-related ischemic vascular disease is on a rapidly increasing trend and has brought a huge burden on the whole society. Vascular aging, characterized by vascular dysfunction and aging of the vasculature, plays a key role in the pathogenesis of ischemic vascular disease, morbidity, and mortality of the elderly. This review describes mechanisms and depicts the novel interventional strategies of vascular aging. We propose the significance of vascular aging for early detection, early prevention, and early treatment of age-related ischemic disease and effective improvement of the quality of life in the elderly population. Finally, future directions to develop novel interventions targeting ischemic disease are presented to prevent age-related vascular pathologies., Competing Interests: Nothing to disclose., (© 2020 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd.)