1. Role of histamine H3 receptor in glucagon-secreting αTC1.6 cells.
- Author
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Nakamura T, Yoshikawa T, Naganuma F, Mohsen A, Iida T, Miura Y, Sugawara A, and Yanai K
- Abstract
Pancreatic α-cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α-cells remains unknown. We found that the histamine H3 receptor (H3R) was expressed in mouse pancreatic α-cells and αTC1.6 cells, a mouse pancreatic α-cell line. H3R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca(2+) concentration. We also found that immepip, a selective H3R agonist, decreased serum glucagon concentration in rats. These results suggest that H3R modulates glucagon secretion from pancreatic α-cells.
- Published
- 2014
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