1. Prognostic significance of body mass index before treatment for head and neck cancer.
- Author
-
Takenaka Y, Takemoto N, Nakahara S, Yamamoto Y, Yasui T, Hanamoto A, Fukusumi T, Michiba T, Cho H, Yamamoto M, and Inohara H
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell mortality, Female, Head and Neck Neoplasms mortality, Humans, Male, Middle Aged, Prognosis, Proportional Hazards Models, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck, Survival Rate, Young Adult, Body Mass Index, Carcinoma, Squamous Cell therapy, Head and Neck Neoplasms therapy, Nutritional Status
- Abstract
Background: Patients with head and neck cancer frequently experience malnutrition. The purpose of this study was to examine the impact of nutritional status on prognosis and its association with treatment modalities., Methods: This retrospective study included 706 patients with head and neck cancer diagnosed between 2004 and 2012. The effects of pretreatment body mass index (BMI) on overall survival were analyzed using the Kaplan-Meier method and Cox regression model., Results: BMI ranged from 11.6 to 38.0 kg/m2 (median, 21.5) and was a prognostic factor for survival, independent of primary site, and tumor stage. The 5-year survival rates for underweight, normal, and overweight groups were 32.2%, 62.7%, and 73.5%, respectively. The hazard ratios of BMI in the surgery, chemoradiation, and radiation groups were 0.95, 0.91, and 0.79, respectively, and the latter two were statistically significant., Conclusion: The impact of BMI is determined by the types of cancer treatment. Pretreatment BMI should be considered while deciding treatment., (© 2014 Wiley Periodicals, Inc.)
- Published
- 2015
- Full Text
- View/download PDF