1. Amyloid‐dependent and amyloid‐independent effects of Tau in individuals without dementia
- Author
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Pamela C.L. Ferreira, Sulantha Mathotaarachchi, Marcus Sefranek, Joseph Therriault, Serge Gauthier, Firoza Z. Lussier, Pedro Rosa-Neto, Tharick A. Pascoal, Paramita Saha-Chaudhuri, Cecile Tissot, Mira Chamoun, Andrea Lessa Benedet, Eduardo R. Zimmer, and Bruna Bellaver
- Subjects
Oncology ,Male ,medicine.medical_specialty ,Amyloid ,Clinical Dementia Rating ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Standardized uptake value ,Neocortex ,tau Proteins ,Cohort Studies ,Internal medicine ,mental disorders ,medicine ,Dementia ,Humans ,Cognitive Dysfunction ,RC346-429 ,Research Articles ,Aged ,Aged, 80 and over ,Amyloid beta-Peptides ,business.industry ,General Neuroscience ,Cognition ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Posterior cingulate ,Positron-Emission Tomography ,Cohort ,Female ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,Amnesia ,business ,RC321-571 ,Research Article - Abstract
Objective To investigate the relationship between the topography of amyloid‐β plaques, tau neurofibrillary tangles, and the overlap between the two, with cognitive dysfunction in individuals without dementia. Methods We evaluated 154 individuals who were assessed with amyloid‐β PET with [18F]AZD4694, tau‐PET with [18F]MK6240, structural MRI, and neuropsychological testing. We also evaluated an independent cohort of 240 individuals who were assessed with amyloid‐β PET with [18F]Florbetapir, tau‐PET with [18F]Flortaucipir, structural MRI, and neuropsychological testing. Using the VoxelStats toolbox, we conducted voxel‐wise linear regressions between amyloid‐PET, tau‐PET, and their interaction with cognitive function, correcting for age, sex, and years of education. Results In both cohorts, we observed that tau‐PET standardized uptake value ratio in medial temporal lobes was associated with clinical dementia rating Sum of Boxes (CDR‐SoB) scores independently of local amyloid‐PET uptake (FWE corrected at p
- Published
- 2021