1. Immunogenicity and clinical effectiveness of the trivalent inactivated influenza vaccine in immunocompromised children undergoing treatment for cancer
- Author
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Catherine H. Cole, Peter Richmond, Peter Jacoby, Rishi S. Kotecha, Ushma D. Wadia, Anne L. Ryan, Ian G. Barr, Nicholas G. Gottardo, Christopher C Blyth, and Anthony D. Keil
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Adolescent ,Influenza vaccine ,chemotherapy ,03 medical and health sciences ,Immunocompromised Host ,0302 clinical medicine ,Influenza A Virus, H1N1 Subtype ,030225 pediatrics ,Internal medicine ,Neoplasms ,Influenza, Human ,Outcome Assessment, Health Care ,medicine ,Odds Ratio ,Humans ,Radiology, Nuclear Medicine and imaging ,Lymphocyte Count ,Seroconversion ,Adverse effect ,Child ,Original Research ,Cancer ,Reactogenicity ,business.industry ,Influenza A Virus, H3N2 Subtype ,Antibody titer ,Clinical Cancer Research ,Infant ,Odds ratio ,vaccination ,Vaccination ,immunocompromised ,pediatric ,Oncology ,Influenza Vaccines ,030220 oncology & carcinogenesis ,Child, Preschool ,Immunology ,Population study ,Female ,Disease Susceptibility ,business ,influenza - Abstract
Influenza is associated with significant morbidity and mortality in children receiving therapy for cancer, yet recommendation for, and uptake of the seasonal vaccine remains poor. One hundred children undergoing treatment for cancer were vaccinated with the trivalent inactivated influenza vaccine according to national guidelines in 2010 and 2011. Influenza‐specific hemagglutinin inhibition antibody titers were performed on blood samples taken prior to each vaccination and 4 weeks following the final vaccination. A nasopharyngeal aspirate for influenza was performed on all children who developed an influenza‐like illness. Following vaccination, seroprotection and seroconversion rates were 55 and 43% for H3N2, 61 and 43% for H1N1, and 41 and 33% for B strain, respectively. Overall, there was a significant geometric mean fold increase to H3N2 (GMFI 4.56, 95% CI 3.19–6.52, P
- Published
- 2015