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17 results on '"Radstake, Timothy R D J"'

1. Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis

Author

CTI Meyaard, Oogheelkunde Onderzoek, CTI Lab support, Translationele immunologie, DBG Metabole en Endocriene Ziekten, Onderzoek Reumatologie, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, MS Oogheelkunde, Child Health, CTI Boes, Onderzoek, CTI Pandit, Servaas, Nila H, Hiddingh, Sanne, Chouri, Eleni, Wichers, Catharina G K, Affandi, Alsya J, Ottria, Andrea, Bekker, Cornelis P J, Cossu, Marta, Silva-Cardoso, Sandra C, van der Kroef, Maarten, Hinrichs, Anneline C, Carvalheiro, Tiago, Vazirpanah, Nadia, Beretta, Lorenzo, Rossato, Marzia, Bonte-Mineur, Femke, Radstake, Timothy R D J, Kuiper, Jonas J W, Boes, Marianne, Pandit, Aridaman, CTI Meyaard, Oogheelkunde Onderzoek, CTI Lab support, Translationele immunologie, DBG Metabole en Endocriene Ziekten, Onderzoek Reumatologie, Infection & Immunity, Lab Reumatologie/Klinische Immunologie, MS Oogheelkunde, Child Health, CTI Boes, Onderzoek, CTI Pandit, Servaas, Nila H, Hiddingh, Sanne, Chouri, Eleni, Wichers, Catharina G K, Affandi, Alsya J, Ottria, Andrea, Bekker, Cornelis P J, Cossu, Marta, Silva-Cardoso, Sandra C, van der Kroef, Maarten, Hinrichs, Anneline C, Carvalheiro, Tiago, Vazirpanah, Nadia, Beretta, Lorenzo, Rossato, Marzia, Bonte-Mineur, Femke, Radstake, Timothy R D J, Kuiper, Jonas J W, Boes, Marianne, and Pandit, Aridaman

Published
2023

3. Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum

Author

Rothwell, Simon, Cooper, Robert G, Lundberg, Ingrid E, Gregersen, Peter K, Hanna, Michael G, Machado, Pedro M, Herbert, Megan K, Pruijn, Ger J M, Lilleker, James B, Roberts, Mark, Bowes, John, Seldin, Michael F, Vencovsky, Jiri, Danko, Katalin, Limaye, Vidya, Selva-O'Callaghan, Albert, Platt, Hazel, Molberg, Øyvind, Benveniste, Olivier, Radstake, Timothy R D J, Doria, Andrea, De Bleecker, Jan, De Paepe, Boel, Gieger, Christian, Meitinger, Thomas, Winkelmann, Juliane, Amos, Christopher I, Ollier, William E, Padyukov, Leonid, Lee, Annette T, Lamb, Janine A, Chinoy, Hector, Myositis Genetics Consortium, Rothwell, Simon, Cooper, Robert G, Lundberg, Ingrid E, Gregersen, Peter K, Hanna, Michael G, Machado, Pedro M, Herbert, Megan K, Pruijn, Ger J M, Lilleker, James B, Roberts, Mark, Bowes, John, Seldin, Michael F, Vencovsky, Jiri, Danko, Katalin, Limaye, Vidya, Selva-O'Callaghan, Albert, Platt, Hazel, Molberg, Øyvind, Benveniste, Olivier, Radstake, Timothy R D J, Doria, Andrea, De Bleecker, Jan, De Paepe, Boel, Gieger, Christian, Meitinger, Thomas, Winkelmann, Juliane, Amos, Christopher I, Ollier, William E, Padyukov, Leonid, Lee, Annette T, Lamb, Janine A, Chinoy, Hector, and Myositis Genetics Consortium

Published
2017

6. Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum

Author

Translationele immunologie, Infection & Immunity, Rothwell, Simon, Cooper, Robert G, Lundberg, Ingrid E, Gregersen, Peter K, Hanna, Michael G, Machado, Pedro M, Herbert, Megan K, Pruijn, Ger J M, Lilleker, James B, Roberts, Mark, Bowes, John, Seldin, Michael F, Vencovsky, Jiri, Danko, Katalin, Limaye, Vidya, Selva-O'Callaghan, Albert, Platt, Hazel, Molberg, Øyvind, Benveniste, Olivier, Radstake, Timothy R D J, Doria, Andrea, De Bleecker, Jan, De Paepe, Boel, Gieger, Christian, Meitinger, Thomas, Winkelmann, Juliane, Amos, Christopher I, Ollier, William E, Padyukov, Leonid, Lee, Annette T, Lamb, Janine A, Chinoy, Hector, Myositis Genetics Consortium, Translationele immunologie, Infection & Immunity, Rothwell, Simon, Cooper, Robert G, Lundberg, Ingrid E, Gregersen, Peter K, Hanna, Michael G, Machado, Pedro M, Herbert, Megan K, Pruijn, Ger J M, Lilleker, James B, Roberts, Mark, Bowes, John, Seldin, Michael F, Vencovsky, Jiri, Danko, Katalin, Limaye, Vidya, Selva-O'Callaghan, Albert, Platt, Hazel, Molberg, Øyvind, Benveniste, Olivier, Radstake, Timothy R D J, Doria, Andrea, De Bleecker, Jan, De Paepe, Boel, Gieger, Christian, Meitinger, Thomas, Winkelmann, Juliane, Amos, Christopher I, Ollier, William E, Padyukov, Leonid, Lee, Annette T, Lamb, Janine A, Chinoy, Hector, and Myositis Genetics Consortium

Published
2017

7. Review: Innate Lymphoid Cells: Sparking Inflammatory Rheumatic Disease?

Author

Unit Opleiding Reumat./Klin. Immunologie, Translationele immunologie, Infection & Immunity, Wenink, Mark H, Leijten, Emmerik F A, Cupedo, Tom, Radstake, Timothy R D J, Unit Opleiding Reumat./Klin. Immunologie, Translationele immunologie, Infection & Immunity, Wenink, Mark H, Leijten, Emmerik F A, Cupedo, Tom, and Radstake, Timothy R D J

Published
2017

9. Impaired Porphyromonas gingivalis-Induced Tumor Necrosis Factor Production by Dendritic Cells Typifies Patients with Rheumatoid Arthritis

Author

Santegoets, Kim C M, Wenink, Mark H., Braga, Felipe A Vieira, Cossu, Marta, Lamers-Karnebeek, Femke B G, Van Riel, Piet L C M, Sturm, Patrick D J, Van Den Berg, Wim B., Radstake, Timothy R D J, Santegoets, Kim C M, Wenink, Mark H., Braga, Felipe A Vieira, Cossu, Marta, Lamers-Karnebeek, Femke B G, Van Riel, Piet L C M, Sturm, Patrick D J, Van Den Berg, Wim B., and Radstake, Timothy R D J

Published
2016

10. Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

Author

López-Isac, Elena, Martín, Jose Ezequiel, Assassi, Shervin, Simeón, Carmen P., Carreira, Patricia, Ortego-Centeno, Norberto, Freire, Mayka, Beltrán, Emma, Narváez, Javier, Alegre-Sancho, Juan J., Fernández-Gutiérrez, Benjamín, Balsa, Alejandro, Ortiz, Ana M., González-Gay, Miguel A., Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Witte, Torsten, Hunzelmann, Nicolas, Distler, Jörg H W, Riekemasten, Gabriella, van der Helm-van Mil, Annette H., de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Voskuyl, Alexandre E., Vonk, Madelon C., Molberg, Øyvind, Merriman, Tony, Hesselstrand, Roger, Nordin, Annika, Padyukov, Leonid, Herrick, Ariane, Eyre, Steve, Koeleman, Bobby P C, Denton, Christopher P., Fonseca, Carmen, Radstake, Timothy R D J, Worthington, Jane, Mayes, Maureen D., Martín, Javier, Ríos, Raquel, Callejas, Jose Luis, Hitos, José Antonio Vargas, Portales, Rosa García, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., García-Hernández, Francisco José, Castillo, Ma Jesús, Ángeles Aguirre, Ma, Gómez-Gracia, Inmaculada, Rodríguez-Rodríguez, Luis, Peña, Paloma García de la, Vicente, Esther, Andreu, José Luis, de Castro, Mónica Fernández, López-Longo, Francisco Javier, Martínez, Lina, Fonollosa, Vicente, Guillén, Alfredo, Castellví, Iván, Espinosa, Gerard, Tolosa, Carlos, Pros, Anna, Carballeira, Mónica Rodríguez, Narváez, Francisco Javier, Rivas, Manel Rubio, Ortiz-Santamaría, Vera, Madroñero, Ana Belén, Díaz, Bernardino, Trapiella, Luis, Sousa, Adrián, Egurbide, María Victoria, Mateo, Patricia Fanlo, Sáez-Comet, Luis, Díaz, Federico, Hernández, Vanesa, Román-Ivorra, José Andrés, Grau, Elena, Alegre-Sancho, Juan José, Blanco García, Francisco J., Oreiro, Natividad, López-Isac, Elena, Martín, Jose Ezequiel, Assassi, Shervin, Simeón, Carmen P., Carreira, Patricia, Ortego-Centeno, Norberto, Freire, Mayka, Beltrán, Emma, Narváez, Javier, Alegre-Sancho, Juan J., Fernández-Gutiérrez, Benjamín, Balsa, Alejandro, Ortiz, Ana M., González-Gay, Miguel A., Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Witte, Torsten, Hunzelmann, Nicolas, Distler, Jörg H W, Riekemasten, Gabriella, van der Helm-van Mil, Annette H., de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Voskuyl, Alexandre E., Vonk, Madelon C., Molberg, Øyvind, Merriman, Tony, Hesselstrand, Roger, Nordin, Annika, Padyukov, Leonid, Herrick, Ariane, Eyre, Steve, Koeleman, Bobby P C, Denton, Christopher P., Fonseca, Carmen, Radstake, Timothy R D J, Worthington, Jane, Mayes, Maureen D., Martín, Javier, Ríos, Raquel, Callejas, Jose Luis, Hitos, José Antonio Vargas, Portales, Rosa García, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., García-Hernández, Francisco José, Castillo, Ma Jesús, Ángeles Aguirre, Ma, Gómez-Gracia, Inmaculada, Rodríguez-Rodríguez, Luis, Peña, Paloma García de la, Vicente, Esther, Andreu, José Luis, de Castro, Mónica Fernández, López-Longo, Francisco Javier, Martínez, Lina, Fonollosa, Vicente, Guillén, Alfredo, Castellví, Iván, Espinosa, Gerard, Tolosa, Carlos, Pros, Anna, Carballeira, Mónica Rodríguez, Narváez, Francisco Javier, Rivas, Manel Rubio, Ortiz-Santamaría, Vera, Madroñero, Ana Belén, Díaz, Bernardino, Trapiella, Luis, Sousa, Adrián, Egurbide, María Victoria, Mateo, Patricia Fanlo, Sáez-Comet, Luis, Díaz, Federico, Hernández, Vanesa, Román-Ivorra, José Andrés, Grau, Elena, Alegre-Sancho, Juan José, Blanco García, Francisco J., and Oreiro, Natividad

Published
2016

11. Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

Author

Genetica Groep Koeleman, Circulatory Health, Brain, Child Health, Translationele immunologie, Infection & Immunity, López-Isac, Elena, Martín, Jose Ezequiel, Assassi, Shervin, Simeón, Carmen P., Carreira, Patricia, Ortego-Centeno, Norberto, Freire, Mayka, Beltrán, Emma, Narváez, Javier, Alegre-Sancho, Juan J., Fernández-Gutiérrez, Benjamín, Balsa, Alejandro, Ortiz, Ana M., González-Gay, Miguel A., Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Witte, Torsten, Hunzelmann, Nicolas, Distler, Jörg H W, Riekemasten, Gabriella, van der Helm-van Mil, Annette H., de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Voskuyl, Alexandre E., Vonk, Madelon C., Molberg, Øyvind, Merriman, Tony, Hesselstrand, Roger, Nordin, Annika, Padyukov, Leonid, Herrick, Ariane, Eyre, Steve, Koeleman, Bobby P C, Denton, Christopher P., Fonseca, Carmen, Radstake, Timothy R D J, Worthington, Jane, Mayes, Maureen D., Martín, Javier, Ríos, Raquel, Callejas, Jose Luis, Hitos, José Antonio Vargas, Portales, Rosa García, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., García-Hernández, Francisco José, Castillo, Ma Jesús, Ángeles Aguirre, Ma, Gómez-Gracia, Inmaculada, Rodríguez-Rodríguez, Luis, Peña, Paloma García de la, Vicente, Esther, Andreu, José Luis, de Castro, Mónica Fernández, López-Longo, Francisco Javier, Martínez, Lina, Fonollosa, Vicente, Guillén, Alfredo, Castellví, Iván, Espinosa, Gerard, Tolosa, Carlos, Pros, Anna, Carballeira, Mónica Rodríguez, Narváez, Francisco Javier, Rivas, Manel Rubio, Ortiz-Santamaría, Vera, Madroñero, Ana Belén, Díaz, Bernardino, Trapiella, Luis, Sousa, Adrián, Egurbide, María Victoria, Mateo, Patricia Fanlo, Sáez-Comet, Luis, Díaz, Federico, Hernández, Vanesa, Román-Ivorra, José Andrés, Grau, Elena, Alegre-Sancho, Juan José, Blanco García, Francisco J., Oreiro, Natividad, Genetica Groep Koeleman, Circulatory Health, Brain, Child Health, Translationele immunologie, Infection & Immunity, López-Isac, Elena, Martín, Jose Ezequiel, Assassi, Shervin, Simeón, Carmen P., Carreira, Patricia, Ortego-Centeno, Norberto, Freire, Mayka, Beltrán, Emma, Narváez, Javier, Alegre-Sancho, Juan J., Fernández-Gutiérrez, Benjamín, Balsa, Alejandro, Ortiz, Ana M., González-Gay, Miguel A., Beretta, Lorenzo, Santaniello, Alessandro, Bellocchi, Chiara, Lunardi, Claudio, Moroncini, Gianluca, Gabrielli, Armando, Witte, Torsten, Hunzelmann, Nicolas, Distler, Jörg H W, Riekemasten, Gabriella, van der Helm-van Mil, Annette H., de Vries-Bouwstra, Jeska, Magro-Checa, Cesar, Voskuyl, Alexandre E., Vonk, Madelon C., Molberg, Øyvind, Merriman, Tony, Hesselstrand, Roger, Nordin, Annika, Padyukov, Leonid, Herrick, Ariane, Eyre, Steve, Koeleman, Bobby P C, Denton, Christopher P., Fonseca, Carmen, Radstake, Timothy R D J, Worthington, Jane, Mayes, Maureen D., Martín, Javier, Ríos, Raquel, Callejas, Jose Luis, Hitos, José Antonio Vargas, Portales, Rosa García, Camps, María Teresa, Fernández-Nebro, Antonio, González-Escribano, María F., García-Hernández, Francisco José, Castillo, Ma Jesús, Ángeles Aguirre, Ma, Gómez-Gracia, Inmaculada, Rodríguez-Rodríguez, Luis, Peña, Paloma García de la, Vicente, Esther, Andreu, José Luis, de Castro, Mónica Fernández, López-Longo, Francisco Javier, Martínez, Lina, Fonollosa, Vicente, Guillén, Alfredo, Castellví, Iván, Espinosa, Gerard, Tolosa, Carlos, Pros, Anna, Carballeira, Mónica Rodríguez, Narváez, Francisco Javier, Rivas, Manel Rubio, Ortiz-Santamaría, Vera, Madroñero, Ana Belén, Díaz, Bernardino, Trapiella, Luis, Sousa, Adrián, Egurbide, María Victoria, Mateo, Patricia Fanlo, Sáez-Comet, Luis, Díaz, Federico, Hernández, Vanesa, Román-Ivorra, José Andrés, Grau, Elena, Alegre-Sancho, Juan José, Blanco García, Francisco J., and Oreiro, Natividad

Published
2016

12. Impaired Porphyromonas gingivalis-Induced Tumor Necrosis Factor Production by Dendritic Cells Typifies Patients with Rheumatoid Arthritis

Author

Translationele immunologie, Infection & Immunity, Unit Opleiding Reumat./Klin. Immunologie, Santegoets, Kim C M, Wenink, Mark H., Braga, Felipe A Vieira, Cossu, Marta, Lamers-Karnebeek, Femke B G, Van Riel, Piet L C M, Sturm, Patrick D J, Van Den Berg, Wim B., Radstake, Timothy R D J, Translationele immunologie, Infection & Immunity, Unit Opleiding Reumat./Klin. Immunologie, Santegoets, Kim C M, Wenink, Mark H., Braga, Felipe A Vieira, Cossu, Marta, Lamers-Karnebeek, Femke B G, Van Riel, Piet L C M, Sturm, Patrick D J, Van Den Berg, Wim B., and Radstake, Timothy R D J

Published
2016

13. Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease

Author

Kienhorst, Laura B E, van Lochem, Ellen, Kievit, Wietske, Dalbeth, Nicola, Merriman, Marilyn E, Phipps-Green, Amanda, Loof, Arnoud, van Heerde, Waander, Vermeulen, Sita, Stamp, Lisa K, van Koolwijk, Elly, de Graaf, Jacqueline, Holzinger, Dirk, Roth, Johannes, Janssens, Hein J E M, Merriman, Tony R, Broen, Jasper C A, Janssen, Matthijs, Radstake, Timothy R D J, Kienhorst, Laura B E, van Lochem, Ellen, Kievit, Wietske, Dalbeth, Nicola, Merriman, Marilyn E, Phipps-Green, Amanda, Loof, Arnoud, van Heerde, Waander, Vermeulen, Sita, Stamp, Lisa K, van Koolwijk, Elly, de Graaf, Jacqueline, Holzinger, Dirk, Roth, Johannes, Janssens, Hein J E M, Merriman, Tony R, Broen, Jasper C A, Janssen, Matthijs, and Radstake, Timothy R D J

Published
2015

14. Brief report: Enrichment of activated group 3 innate lymphoid cells in psoriatic arthritis synovial fluid

Author

Leijten, Emmerik F A, van Kempen, Tessa S., Boes, Marianne, Michels-van Amelsfort, Jocea M R, Hijnen, Dirkjan, Hartgring, Sarita A Y, van Roon, Joel A G, Wenink, Mark H., Radstake, Timothy R D J, Leijten, Emmerik F A, van Kempen, Tessa S., Boes, Marianne, Michels-van Amelsfort, Jocea M R, Hijnen, Dirkjan, Hartgring, Sarita A Y, van Roon, Joel A G, Wenink, Mark H., and Radstake, Timothy R D J

Published
2015

15. Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease

Author

Unit Opleiding Dermatologie, Translationele immunologie, Infection & Immunity, Unit Opleiding Aios, Kienhorst, Laura B E, van Lochem, Ellen, Kievit, Wietske, Dalbeth, Nicola, Merriman, Marilyn E, Phipps-Green, Amanda, Loof, Arnoud, van Heerde, Waander, Vermeulen, Sita, Stamp, Lisa K, van Koolwijk, Elly, de Graaf, Jacqueline, Holzinger, Dirk, Roth, Johannes, Janssens, Hein J E M, Merriman, Tony R, Broen, Jasper C A, Janssen, Matthijs, Radstake, Timothy R D J, Unit Opleiding Dermatologie, Translationele immunologie, Infection & Immunity, Unit Opleiding Aios, Kienhorst, Laura B E, van Lochem, Ellen, Kievit, Wietske, Dalbeth, Nicola, Merriman, Marilyn E, Phipps-Green, Amanda, Loof, Arnoud, van Heerde, Waander, Vermeulen, Sita, Stamp, Lisa K, van Koolwijk, Elly, de Graaf, Jacqueline, Holzinger, Dirk, Roth, Johannes, Janssens, Hein J E M, Merriman, Tony R, Broen, Jasper C A, Janssen, Matthijs, and Radstake, Timothy R D J

Published
2015

16. Brief report: Enrichment of activated group 3 innate lymphoid cells in psoriatic arthritis synovial fluid

Author

Translationele immunologie, Infection & Immunity, Immuno/reuma onderzoek 2 (Boes), Child Health, CTI Boes, MS Reumatologie/Immunologie/Infectie, MS Dermatologie/Allergologie, Unit Opleiding Reumat./Klin. Immunologie, Leijten, Emmerik F A, van Kempen, Tessa S., Boes, Marianne, Michels-van Amelsfort, Jocea M R, Hijnen, Dirkjan, Hartgring, Sarita A Y, van Roon, Joel A G, Wenink, Mark H., Radstake, Timothy R D J, Translationele immunologie, Infection & Immunity, Immuno/reuma onderzoek 2 (Boes), Child Health, CTI Boes, MS Reumatologie/Immunologie/Infectie, MS Dermatologie/Allergologie, Unit Opleiding Reumat./Klin. Immunologie, Leijten, Emmerik F A, van Kempen, Tessa S., Boes, Marianne, Michels-van Amelsfort, Jocea M R, Hijnen, Dirkjan, Hartgring, Sarita A Y, van Roon, Joel A G, Wenink, Mark H., and Radstake, Timothy R D J

Published
2015

17. Differential isoform expression of Allergin-1 during acute and chronic inflammation.

Author

Geerdink RJ, Pascoal Ramos MI, van den Hoogen LL, Radstake TRDJ, Shibayama S, Shibuya A, Bont L, and Meyaard L

Subjects
Animals, Child, Humans, Mice, Neutrophils, Protein Isoforms genetics, Respiratory Syncytial Viruses, Bronchiolitis, Inflammation genetics, Inflammation metabolism, Receptors, Immunologic genetics, Receptors, Immunologic metabolism, Respiratory Syncytial Virus Infections genetics, Respiratory Syncytial Virus Infections metabolism
Abstract

Introduction: Neutrophils are crucial to antimicrobial defense, but excessive neutrophilic inflammation elicits immune pathology. Currently, no effective treatment exists to curb neutrophil activation. However, neutrophils express a variety of inhibitory receptors which may represent potential therapeutic targets to limit neutrophilic inflammation. Indeed, we previously showed that the inhibitory collagen receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) regulates neutrophilic airway inflammation and inhibits neutrophil extracellular trap formation. The inhibitory receptor Allergin-1 is expressed by myeloid cells and B cells. Allergin-1 suppresses mast cell and basophil activation, but a potential regulatory role on neutrophils remains unexplored. We aimed to demonstrate the regulation of neutrophils by Allergin-1., Methods: We examine Allergin-1 isoform expression on human neutrophils during homeostatic (healthy donors) and chronic inflammatory (systemic lupus erythematosus patients) conditions in comparison to other circulating leukocytes by flow cytometry. To reveal a potential role for Allergin-1 in regulating neutrophilic inflammation, we experimentally infect wild-type (WT) and Allergin-1-deficient mice with a respiratory syncytial virus (RSV) and monitor disease severity and examine cellular airway infiltrate. Flow cytometry was used to confirm Allergin-1 expression by airway-infiltrated neutrophils in RSV infection-induced bronchiolitis patients., Results: Only the short 1 (S1) isoform, but not the long (L) or S2 isoform could be detected on blood leukocytes, with the exception of nonclassical monocytes, which exclusively express the S2 isoform. Allergin-1 expression levels did not vary significantly between healthy individuals and patients with the systemic inflammatory disease on any interrogated cell type. Airway-infiltrated neutrophils of pediatric RSV bronchiolitis patients were found to express Allergin-1S1. However, Allergin-1-deficient mice experimentally infected with RSV did not show exacerbated disease or increased neutrophil airway infiltration compared to WT littermates., Conclusion: Allergin-1 isoform expression is unaffected by chronic inflammatory conditions. In stark contrast to fellow inhibitory receptor LAIR-1, Allergin-1 does not regulate neutrophilic inflammation in a mouse model of RSV bronchiolitis., (© 2022 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)

Published
2022
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