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Objective We aimed to determine the minimum clinically important difference (MCID) of three different item versions of the Constitution in Chinese Medicine Questionnaire (CCMQ), to facilitate the clinical application of CCMQ. Methods In total, 537 subjects were included in the analysis. All subjects voluntarily completed a comprehensive of traditional Chinese medicine ( TCM) constitution intervention (mood, diet, daily living, exercise, and acupoints). The subjects filled out the 60-item CCMQ and the Short Form Health Questionnaire (SF-36) at baseline and 3 months after the intervention. The result of the 41-item and the 30-item CCMQ were scored according to the result of the 60-item CCMQ. An anchor-based approach and a distribution-based approach were used to estimate the MCID of the three versions of the CCMQ. The anchor of the anchor-based approach was SF-36 item 1, and the analysis method were the mean change method and multiple linear regression. The standardized response mean ( SRM) was used for the distribution-based approach. Results The mean change method and multiple linear regression estimation result were averaged and rounded to whole numbers. The MCID values of the 60-item CCMQ of balanced type, qi-deficiency type, yang-deficiency type, yin-deficiency type, phlegm-dampness type, dampness-heat type, blood-stasis type, qi-depression type, and special diathesis type were 5, -5, -3, -3, -4, -4, -4, -4, and -2, respectively. The MCID values of the 41-item CCMQ were 4, -6, -4, -2, -4, -4, -4, -4, and -2, respectively. The MCID values of the 30-item CCMQ were 5, - 5, - 4, - 3, - 4, - 5, - 4, - 5, and - 2, respectively. The MCID values estimated by the anchor-based approach were higher than those estimated when SRM was 0. 2, except for the special diathesis type. Conclusion The MCID values of three different versions of the CCMQ estimated in this study can reflect the minimum score change of the CCMQ considered important and meaningful by patients, which is helpful for doctors in explaining the effect of TCM constitution intervention or setting intervention targets. [ABSTRACT FROM AUTHOR]

Objective A holistic and comprehensive analysis of traditional Chinese medicine (TCM) constitutions health states was conducted to explore the impact of different concurrently clamped constitution histories on health-related quality of life (HRQOL). Methods　Using the convenient sampling method, the Constitution in Chinese Medicine Questionnaire-41 entry short version, the Chinese verison of SF- 36, and other tools were used to measure the unpaid blood donor population aged 18 to 60 years old, and the fuzzy set qualitative comparative analysis was used to explore configuration of the TCM constitution that affected HRQOL. Results The mean age of the 2 254 study subjects included in the analysis was (30. 72±9. 78) years. The percentage of gentleness constitution was 35. 71%, and 33. 81% had a combination of more than 3 types biased constitutions. Three categories of TCM constitution groupings negatively influenced HRQOL in the physiological domain. First, non-gentleness constitution, qi-deficiency constitution, yang-deficiency constitution, phlegm-wetness constitution, and blood-stasis constitution were the core conditions; second, non-gentleness constitution, qi-deficiency constitution, phlegm-wetness constitution, blood-stasis constitution and special diathesis constitution were the core conditions; and third, all eight biased constitutions were present as core conditions. Three categories of TCM constitution groupings negatively influenced HRQOL in the psychological domain. First, non-gentleness constitution, qideficiency constitution, phlegm-wetness constitution, blood-stasis constitution, and qi-depression constitution were the core conditions; second, non-gentleness constitution, qi-deficiency constitution, yin-deficiency constitution, wetness-heat constitution, and qi-depression constitution were the core conditions; and third, all eight biased constitutions occurred as core conditions. Conclusion　The fuzzyset qualitative comparative analysis method with a configuration perspective revealed the effect of TCM constitution on HRQOL as a multi-component combination of concurrent mechanisms. The diversity of concurrently clamped constitution and the complexity of its relationship with HRQOL were fully analyzed, and this results provide a reference direction for researchers to dig deeper into the intervention pathways of TCM constitution conditioning to enhance quality of life. [ABSTRACT FROM AUTHOR]

Abstract:Objective We aimed ( ⅰ) to explore the correlation between the public′s acute stress reaction( ASR) and the constitution of traditional Chinese medicine ( TCM) during the COVID-19 epidemic and (ⅱ) to provide a basis for adjusting the constitution bias and improving the public′s ability to cope with COVID-19 under the normalized management of the epidemic. Methods From February 3 to February 15, 2022, an electronic questionnaire survey was conducted using a combination of convenient sampling and snowball sampling. Statistics of basic information (gender, age, marital status, educational background, the likelihood of believing that they are infected, the likelihood of believing that people around them are infected, whether the location is a risk area, and whether they have been vaccinated against COVID-19 ), the scores of the Stanford Acute Stress Reaction Questionnaire (SASRQ), and TCM constitution transformation scores of each subscale of a 30-Item Short Version of Constitution in Chinese Medicine Questionnaire ( CCMQ - 30) were calculated. Those with a SASRQ score of ≥40 were included in the ASR group, and those with a SASRQ score of <40 were included in the non-ASR group. The basic information and TCM constitution of the two groups were compared. Spearman correlation analysis and multiple linear regression analysis were performed to examine the correlation between the total SASRQ score and the transformation score of each CCMQ- 30 subscale. Results A total of 1 218 questionnaires were collected, of which 116 invalid questionnaires were excluded, so 1 102 samples were included in the final analysis. The effective rate of the questionnaire was 90. 48%. (ⅰ) There were 892 people in the non-ASR group and 210 people in the ASR group. There were no significant differences in gender, age, marital status, educational background, whether the location was a risk area, the possibility of infection, and vaccination between the two groups (P>0. 05), while there were significant differences in the possibility of believing that people around them are infected (P<0. 05); the proportion of people who perceived the possibility of infection was higher in the ASR group than in the non-ASR group. (ⅱ) There were significant differences in the scores of nine TCM constitutions between the ASR group and the non-ASR group (P< 0. 05). Correlation analysis showed that the total SASRQ score was negatively correlated with balanced constitution (r = -0. 353, P<0. 01), while it was positively correlated with eight biased constitutions; ordered based on the correlation from strong to weak, these constitutions were the following: qi-stagnation, qi-deficiency, blood-stasis, phlegm-dampness, inherited special, yin-deficiency, dampness-heat, and yang-deficiency (r = 0. 235 to 0. 367, P < 0. 01). ( ⅲ) Multiple linear regression analysis controlling for the interaction of biased constitutions showed that qi-stagnation( β′ = 0. 214, P<0. 01), qi-deficiency ( β′ = 0. 139, P<0. 05), and inherited special constitution ( β′ = 0. 088, P < 0. 01) were the independent influencing factors of ASR. Further control for confounding variables yielded similar result. Conclusion Qi-stagnation, qideficiency, and inherited special constitution have a great influence on public ASR. It is suggested to focus on adjusting qi-stagnation, qi-deficiency, and inherited special constitution to improve public physical and mental health under the normal management of the COVID-19 epidemic. [ABSTRACT FROM AUTHOR]

Objective　To develop the knowledge-attitude-practice(KAP) scale for preventive treatment of disease through constitution of Chinese medicine(KAP-PTDCCM) and test its reliability and validity, in order to provide an assessing tool for health management in preventive treatment through constitution of Chinese medicine. Methods　The KAP-PTDCCM was initially developed by referring to literature review combined with expert opinion based on the KAP Theory. A convenience sample of 922 students from three universities in Xinjiang and Beijing were investigated. Reliabilities of KAP-PTDCCM were tested by internal consistency reliability and split-half reliability. Validities of KAP-PTDCCM were tested by construct validity, convergent validity and discriminant validity. Results　The KAP-PTDCCM consisted of 24 items belonging to three dimensions: Knowledge(8 items), Belief/ Attitude(9 items), and Practice (7 items). The total Cronbach′s α value of KAP-PTDCCM was 0. 925(>0. 9) and varied from 0. 887 to 0. 943(>0. 8) for its three dimensions. Split-half reliability was 0. 960. Results of exploratory factor analysis were in accordance with KAP theory, and the cumulative contribution rate of the top three factors was 66. 33%. The indexes of confirmatory factor analysis showed a good fitness of the model. Convergent validity showed that correlation coefficients ranged from 0. 538 to 0. 838(P<0. 05), and discriminant validity showed that correlation coefficients ranged from 0. 096 to 0. 541(P<0. 05). The successful rate was 100% according to the convergent validity and discriminant validity tests. Conclusion　The 24-item scale of KAP-PTDCCM seems to show good reliability and validity for the application in evaluating the knowledge, attitude, practice, and health management effect of preventive treatment of disease through constitution of Chinese medicine. [ABSTRACT FROM AUTHOR]

Objective To explore the intervention effect of TCM constitution health education on constitution and relevant health indicators. Methods The research design was adopted with no control group before and after the test evaluation. A total of 595 subjects were recruited. Interventions of emotion, diet, sleeping and living, exercise, and meridian and acupoint massage were concluded in the TCM constitution health education interventions. Investigated their constitution, health related quality of life(MOSSF-36) and laboratory indexes before and after the intervention of 3 months and 6 months. Results 509 subjects were available. After 3 months intervention, the score of gentleness type was significantly increased by 3.67 points (P＜0.05) while scores of pathological constitutions except yang-deficiency type were significantly decreased (P＜0.05). All of the absolute values of standardized response mean (SRM) ranged from 0.10 to 0.51. After 6 months intervention, the score of gentleness type was significantly increased by 3.67 points (P＜0.05) while scores of all pathological constitutions were significantly decreased (P＜0.05). All of the absolute values of SRM ranged from 0.23 to 0.75. Physical component summary (PCS) scores and mental component summary (MCS) scores of MOS SF-36 were significantly increased (P＜0.05) after 3 months and 6 months intervention. After 3 months intervention, systolic pressure (SP), diastolic pressure (DP), 2-hour postprandial glucose (2hPG), and total cholesterol (TC) decreased significantly (P＜0.05), but high density lipoprotein-cholesterol (HDL-C) was significantly increased (P＜0.05). After 6 months intervention, SP, DP, 2hPG, TC, triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) were significantly decreased (P＜0.05), but HDL-C was significantly increased (P＜0.05). Conclusion TCM constitution Health education intervention can improve the constitutional conditions, clinical abnormal indexes, and the quality of life resulting in the improvement of health. However, the intervention effects were generally low, which indicates that the constitution is relatively stable. Therefore, a long-term of TCM constitution intervention is necessary for health promotion. [ABSTRACT FROM AUTHOR]