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Background: Renal resistive index is a recognised and early indicator of type II diabetes mellitus-related cardiovascular risk as well as diabetic nephropathy. Aim: To determine the relationship between resistive index and estimated glomerular filtration rate of subjects with diabetic nephropathy and to determine the frequency of occurrence of high resistive index in subjects with diabetic nephropathy. Material and methods: The present cross sectional study entitled to study the correlation of renal resistive index and estimated glomerular filtration rate in diabetic nephropathy was conducted on 50 patients of type 2 diabetes mellitus with the diabetic nephropathy with reduced renal function (stage G1-G5), attending outdoor department or admitted in Medicine Department of Guru Nanak Dev Hospital, attached to Government Medical College, Amritsar. Results: Out of 50 patients, females comprise 22 (44%) and males 28 (56%). The mean egfr in patients with RI <0.7 was 28.5 and in patients with >0.7 was 20.1. The difference was significant (P< 0.05). The mean RI in patients with CKD stage 2 was 0.65, in patients with stage 3was 0.69, in patients with stage 4 was 0.74 and in patients with stage 5 was 0.78. A significant difference was observed (P< 0.05). Conclusion: Renal RI could be a useful complementary test for the evaluation of functional alterations in renal hemodynamics in the early stages of diabetic nephropathy. [ABSTRACT FROM AUTHOR]