1. Effects of Baobaole oral liquid on neuron excitability of feeding center in anorectic rats
- Author
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Yue-ping Zhang, Yong-ping Du, and Guo-cheng Zhang
- Subjects
medicine.medical_specialty ,media_common.quotation_subject ,Spleen ,Stimulation ,Rats, Sprague-Dawley ,Random Allocation ,Internal medicine ,medicine ,Extracellular ,Animals ,media_common ,Neurons ,business.industry ,Excitatory Postsynaptic Potentials ,Vagus Nerve ,Appetite ,Anorexia ,Rats ,Peripheral ,medicine.anatomical_structure ,Endocrinology ,Animals, Newborn ,Complementary and alternative medicine ,Ventromedial Hypothalamic Nucleus ,Hypothalamic Area, Lateral ,Excitatory postsynaptic potential ,Anorectic ,Neuron ,business ,Drugs, Chinese Herbal ,Phytotherapy - Abstract
OBJECTIVE To investigate the effects of Baobaole oral liquid on neuronal excitability in lateral hypothalamic area (LHA) and ventromedial hypothalamic nuclear (VMN) in anorectic rats. METHODS The anorectic rat model was established by feeding with special prepared forage for a week, and then Baobaole oral liquid, a liquid extract of a compound traditional Chinese medicine for activating spleen, was administered once a day for 3 weeks. Finally, extracellular recording from LHA and VMN neurons in rats were made in order to characterize their responses to gastric vagal nerve stimulation and intravenous injection of glucose in the normal, untreated, and Baobaole-treated groups. RESULTS There was no statistical difference in response characteristics of LHA neurons to gastric vagal stimulation among 3 groups. The duration of VMN neuron excitation response to gastric vagal nerve stimulation in the untreated group was significantly longer than that of the normal control group (P
- Published
- 2007
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