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ABSTRACT A hydroquinone/tretinoin (HQ/tret) skin care system designed for use with non-surgical facial rejuvenation procedures has recently become available. In this observer-masked study, 36 patients with moderate-to-severe wrinkling of the [...]

ABSTRACT Synergistic interaction of multiple growth factors (GF) in skin controls the processes that promote skin repair. GFs have been shown to affect different pathways of skin repair and rejuvenation [...]

ABSTRACT Introduction: Skin resurfacing has evolved rapidly over the past 15 years from ablative techniques to nonablative methods and most recently fractional ablative resurfacing. The purposes of this study were [...]

ABSTRACT Objective: Review the safety profile and subjective efficacy of intradermal botulinum toxin type A in facial pore size and sebum production. Design: Retrospective analysis of 20 patients. Results: Twenty [...]

Abstract Background: Hand dermatitis is a chronic inflammatory skin disorder for which systemic immunosuppressive therapy is often needed. Topical treatments could complement the use of systemic corticosteroids. Objective: To evaluate [...]

Abstract Background: There have been many reports of topical steroids treatment for the face causing perioral dermatitis, steroid acne, and steroid rebound phenomenon. Objective: To assess patient reported outcomes in [...]

Abstract The Roberts Skin Type Classification System is a 4-part serial system that comprehensively identifies a patient's skin type characteristics, and provides data to predict the skin's likely response to [...]

Background: Hydrocortisone butyrate (HCB) is currently marketed as a cream, ointment, and solution. A new lotion formulation of hydrocortisone butyrate 0.1% (Locoid[R] lotion) has been developed and evaluated. Objective: The objective of this study was to evaluate the efficacy and safety of HCB 0.1% lotion compared to the vehicle in subjects aged 3 months to less than 18 years with mild to moderate atopic dermatitis (AD). Methods: In this multicenter double-blind study, 284 subjects with mild to moderate AD were randomized 1:1 to receive HCB 0.1% lotion or the vehicle for a duration of 4 weeks. 'Treatment success' was defined as those subjects with a final Physician Global Assessment (PGA) score of 0 or 1 that had at least a 2-point reduction in the PGA score from baseline to day 29. Safety was assessed by monitoring adverse events. Results: Analyses of the final PGA score showed a significant treatment effect (P Limitations: The study did not assess the durability of the treatment effects (ie, safety and efficacy) after completion of the 4-week treatment period nor the potential need for longer term therapy given the chronic nature of AD. Conclusion: Results demonstrate the safety and efficacy of HCB 0.1% lotion in the treatment of mild to moderate AD in children 3 months to 18 years of age., Introduction Topical corticosteroids have become the cornerstone of treatment for a variety of inflammatory dermatoses, including atopic dermatitis (AD), eczema, and psoriasis. A wide selection of topical corticosteroid products is [...]

It is becoming widely accepted that volume changes in the skin and soft tissue contribute greatly to age-related facial reshaping. A significant contribution to these volume changes is the loss of craniofacial skeletal support to the overlying soft tissue. Gravity, once considered the major culprit in facial aging, is now recognized to determine the direction, rather than the extent, of tissue deflation. Although the sequence of events observed in aging is somewhat predictable, its pace among individuals is variable and may be influenced by both intrinsic (eg, gender, genetics) and extrinsic (eg, photoaging, smoking, stress) factors. Changes in different tissue layers within a single individual do not occur independently, but interdependently; changes in one tissue within an individual may influence subsequent changes in other tissues. Midfacial soft tissue descent has been observed in response to decreased craniofacial support in both congenital craniofacial hypoplasia and following trauma, leading to a hypothesis that the loss of underlying bony support for any reason, including aging, leads to soft tissue descent in the face. As craniofacial support (the 'table') decreases, it leaves less surface area for the outer soft tissue envelope (the 'tablecloth') causing it to fold or sag. Replacing this deep support with craniofacial implants has been shown to reposition the overlying soft tissue. Following a brief review of the current literature on aging changes in the skin, soft tissue, and bone; the authors describe their experience with the use of poly-L-lactic acid (PLLA), both as a soft tissue volumizer and as an injectable craniofacial implant in a supraperiosteal location to address both soft tissue volume loss and loss of craniofacial support. In the cases presented, the most striking result noted was the ability to restore a youthful proportion to the perioral area, which had not been achieved previously with soft tissue treatment alone., Introduction Facial beauty and attractiveness are important cross-cultural social concepts as they tend to dictate how individuals are judged and treated. (1) Research has shown that facial beauty is perceived [...]

Introduction: Results from clinical observations have demonstrated that percutaneous infiltration of carbon dioxide improves the appearance of the skin in adjacent areas. No studies have been found in the literature that showed evidence of histological changes caused by carbon dioxide injections. Objectives and Methods: A blind cross-sectional pilot study was performed in the Departments of Pharmacology and Morphology of the Federal University of Ceara, with the aim of histologically investigating whether intradermal and/or subcutaneous injection of medicinal carbon dioxide would increase collagen turnover in rats. Ten male Wistar rats were used, aged 3 months (2 animals) and 14 months (8 animals). The 2 younger rats were used as controls. Four of the older rats received injections of saline solution (0.9%), and were also considered to be controls. In the remaining 4, carbon dioxide was injected into the subcutaneous cellular tissue and intradermally. Biopsy samples were collected before and after treatment with carbon dioxide. Results: Collagen turnover increased in the treated animals in comparison with the controls. Compression of collagen bundles in the tissue samples where intradermal injection was used was more intense than in the subcutaneous treatment. The histological characteristics of the samples with carbon dioxide injected intradermally were similar to the characteristics of the younger rats (controls). Conclusions: The results obtained corroborate clinical observations of aesthetic improvements in the facial skin with carbon dioxide injections. Future research should address the comparison between intradermal and subcutaneous injections, the volume of gas used, and the frequency of treatment sessions., Introduction Human tissue changes with age. In the skin, these modifications are more easily recognized. (1,2) The modifications to the collagen and elastin system cause wrinkles, atrophy, grooves, ptosis, and [...]

Abstract Background: Carbon dioxide laser resurfacing remains the gold standard for the treatment of photoaged skin. Today, however, fewer patients will tolerate the postoperative downtime associated with the use of [...]

Abstract Background: Topical photodynamic therapy (PDT) involves the use of a photosensitizing topical medication that is activated by a light source in the presence of oxygen leading to cellular destruction [...]

Abstract This study evaluates the efficacy and tolerability of an investigational study cream composed of 3 ingredients (green and white teas, mangosteen, and pomegranate extract), Vitaphenol[TM] Skin Cream (La Jolla [...]

Abstract Background and Objective: Studies documenting improvement following combined laser and light-based devices are needed. The objective of this study was to evaluate clinical, histological, and ultrastructural changes in photodamaged [...]

Abstract Topical anesthetic agents are frequently used by dermatologists to decrease the pain associated with a variety of cutaneous procedures, including laser surgery, soft tissue augmentation, and other cosmetic surgical [...]

Abstract Growth factors, in addition to their crucial role in cutaneous wound healing, are also beneficial for skin rejuvenation. Due to their multifunctional activities such as promoting skin cell proliferation [...]

Abstract Evidence of the signs associated with skin aging often first appears in the periorbital area and includes wrinkles, eyelid bags, circles around the eye, or a 'tired' look. This [...]

Abstract Backround/Objectives: The signs of aging may originate from natural processes or from exposure to the sun, wind, or other environmental factors. To evaluate the anti-aging effects of potential agents [...]

Abstract Background and Objectives: Ultraviolet (UV) light produces reactive oxygen species (ROS) in skin, which accelerate aging by damaging DNA, proteins, lipids, and other cellular constituents. The aims of this [...]

Abstract Background and Objectives: Cell longevity is linked to sirtuins (silent information regulators), which belong to a family of enzymes implicated in gene silencing, apoptosis, fatty acid metabolism, and regulation [...]

ABSTRACT Prior to 1962, some of the most versatile drugs in dermatology were approved by the U.S. Food and Drug Administration (FDA) solely on the basis of safety. One of [...]

Sponsored by FDA Office of Orphan Products Development. Collaborator: Boston University. This is a randomized, multi-center study. Patients are randomized to one of two treatment arms. Arm 1: Patients receive [...]

INTRODUCTION The recent controversy of botulinum toxin and potential neurotoxicity to the brain has spurred on a tremendous amount of concern on the part of patients seeking this treatment for [...]

Abstract Amidst the ban on federal funding for most stem cell research, recent developments have been made in generating stem cells without using human embryos. One novel approach is to [...]

A recent report indicates that photodynamic therapy (PDT), topical 5-aminolevulinic acid (5-ALA) and the exposure to a light source, may produce molecular changes that improve the appearance of aging skin. [...]

Sponsors and Collaborators: North Central Cancer Treatment Group and National Cancer Institute (NCI). This randomized phase III trial is studying mometasone furoate to see how well it works compared to [...]

Sponsored by University of Michigan. This research project aims to study the effects of microdermabrasion. Condition Intervention Healthy Skin Procedure: Microdermabrasion Skin Wrinkling Study ID Numbers: Derm 486 ClinicalTrials.gov Identifier: [...]