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Origanum glandulosum an endemic species of Algeria and Tunisia is widely used to cure effectively various infectious diseases and has been long claimed to have hypogylcemic-hypolipidemic dual effects in folkloric medicine. The current manuscript summarizes a significant amount of work that was undertaken to identify Algerian oregano with potential α-amylase and pancreatic lipase inhibitory activities. In addition, we have compared the inhibitory activities of purified constituent (Rosmarinic acid) found in O. glandulosum to the parent plant. Our results show that both oregano extract and pure compound react with porcine pancreatic amylase and lipase. Rosmarinic acid isolated from Origanum showed to inhibit the α-amylase and lipase activities in a dose dependent manner, but not higher than the ethyl acetate extract suggesting that others phenolics compounds or phenolic synergies may contribute to additional inhibitory activity. The observed inhibitions of α-amylase and lipase suggest that the extract of O. glandulosum may be useful in the management of diabetes mellitus, which may due to the presence of active phytochemicals., Journal of International Society of Antioxidants in Nutrition & Health, Vol 3, No 1 (2016): Journal of ISANH Volume 3: Special Issue for Antioxidants Middle East