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Objective To investigate the application effect of wax therapy combined with Reyanbao in patients with knee osteoarthritis with wind-cold-dampness impediment type. Methods A total of 114 patients with wind-cold-dampness arthralgia syndrome from January 2020 to November 2021 were randomly divided into three groups:groups A(the control group), B(the wax therapy group) and C(the wax therapy combined with traditional Chinese medicine Yanbao group), with 38 cases in each group. Group A received routine treatment and HYJ anti-inflammatory machine(Chongqing Shuming Technology Development Co., Ltd., HYJ-III) and intermediate frequency therapy(Chengdu Qianli Electronic Equipment Co., Ltd. ). Group B received wax therapy on the basis of routine treatment, and group C received wax therapy combined with self-made traditional Chinese medicine Yanbao on the basis of routine treatment. After two weeks, the scores of quality of life measurement(AIMS2-SF), pain score and the total score of osteoarthritis efficacy index of McMaster University in Western Ontario, Canada were compared before and after treatment. Results The pain score of group C was lower than that of the first two groups, and the quality of life score of group C was more than 86, which was higher than that of the other two groups. After treatment, the total treatment efficiency of group C was 97. 3%, the total effective rate of group B was 76. 3%, and the total effective rate of group A was 50. 0%. Conclusion Wax therapy combined with self-made traditional Chinese medicine Yanbao is safe and effective in the treatment of patients with wind-cold-dampness arthritic knee osteoarthritis, and can effectively improve the quality of life of patients. [ABSTRACT FROM AUTHOR]