4 results on '"Stephanie H. Chen"'
Search Results
2. Endoscopic third ventriculostomy with choroid plexus cauterization for the treatment of infantile hydrocephalus in Haiti
- Author
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Iahn Cajigas, John Ragheb, Ariel Henry, Ernest J. Barthélemy, George M. Ibrahim, Stephanie H Chen, Ashish H. Shah, Yudy Lafortune, and Michael Ragheb
- Subjects
Ventriculostomy ,medicine.medical_specialty ,Univariate analysis ,Multivariate analysis ,business.industry ,medicine.medical_treatment ,Endoscopic third ventriculostomy ,General Medicine ,Infantile hydrocephalus ,medicine.disease ,Surgery ,Hydrocephalus ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,medicine ,Cauterization ,Choroid plexus ,business ,030217 neurology & neurosurgery - Abstract
OBJECTIVEUntreated hydrocephalus poses a significant health risk to children in the developing world. In response to this risk, global neurosurgical efforts have increasingly focused on endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC) in the management of infantile hydrocephalus in low- and middle-income countries (LMICs). Here, the authors report their experience with ETV/CPC at the Hospital Bernard-Mevs/Project Medishare (HBMPM) in Port-au-Prince, Haiti.METHODSThe authors conducted a retrospective review of a series of consecutive children who had undergone ETV/CPC for hydrocephalus over a 1-year period at HBMPM. The primary outcome of interest was time to ETV/CPC failure. Univariate and multivariate analyses using a Cox proportional hazards regression were performed to identify preoperative factors that were associated with outcomes.RESULTSOf the 82 children who underwent ETV/CPC, 52.2% remained shunt free at the last follow-up (mean 6.4 months). On univariate analysis, the ETV success score (ETVSS; p = 0.002), success of the attempted ETV (p = 0.018), and bilateral CPC (p = 0.045) were associated with shunt freedom. In the multivariate models, a lower ETVSS was independently associated with a poor outcome (HR 0.072, 95% CI 0.016–0.32, p < 0.001). Two children (2.4%) died of postoperative seizures.CONCLUSIONSAs in other LMICs, ETV/CPC is an effective treatment for hydrocephalus in children in Haiti, with a low but significant risk profile. Larger multinational prospective databases may further elucidate the ideal candidate for ETV/CPC in resource-poor settings.
- Published
- 2020
3. Closure of a giant anterior sacral meningocele with an omental flap in a patient with Marfan syndrome: case report
- Author
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Allan D. Levi, Kenneth M. Crandall, Gabriella Paisan, Laurence R. Sands, Stephanie H Chen, and S. Shelby Burks
- Subjects
Adult ,Marfan syndrome ,Sacrum ,Tarlov cyst ,medicine.medical_specialty ,Decompression ,Omental flap ,Meningocele ,Surgical Flaps ,Marfan Syndrome ,03 medical and health sciences ,0302 clinical medicine ,Anterior sacral meningocele ,medicine ,Humans ,Cyst ,business.industry ,General Medicine ,respiratory system ,Pelvic cavity ,Decompression, Surgical ,musculoskeletal system ,medicine.disease ,respiratory tract diseases ,Surgery ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,Presentation (obstetrics) ,business ,030217 neurology & neurosurgery - Abstract
Anterior sacral meningoceles (ASMs) are rare lesions often associated with connective tissue disorders. These lesions are typically treated posteriorly via closure of the dural stalk. However, given their insidious nature, ASMs can be quite large on presentation, and this approach may not provide adequate decompression. In this case report, the authors describe the successful treatment of a large ASM through drainage and watertight closure of the cyst with an omental flap.A 43-year-old woman with a history of Marfan syndrome and a large ASM was referred for neurosurgical intervention. The ASM was filling the pelvic cavity and causing severe compression of the bladder. The patient underwent surgical decompression of the cyst through an anterior transabdominal approach and closure of the fistulous tract with a pedicled omental flap. This is the first reported case of successful closure of an ASM with an omental flap. At the 6-month follow-up, the ASM had not recurred on imaging and the patient’s symptoms had resolved.Anterior sacral meningoceles are rare lesions that often require neurosurgical intervention. Although most can be treated posteriorly, large ASMs compressing the abdominal or pelvic organs may require a transabdominal approach. Moreover, ASMs with wide dural stalks may benefit from closure with an omental flap.
- Published
- 2018
4. Radiosurgery for benign tumors of the spine using the Synergy S with cone-beam computed tomography image guidance
- Author
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John C. Flickinger, Yuanguang Xu, Josef Novotny, Stephanie H. Chen, Mubina Quader, and Peter C. Gerszten
- Subjects
Cone beam computed tomography ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General Medicine ,Schwannoma ,medicine.disease ,Spine radiosurgery ,Radiosurgery ,Meningioma ,Lumbar ,medicine ,Neurofibroma ,Radiology ,Nuclear medicine ,business ,Image guidance - Abstract
Object There is a growing body of evidence to support the safe and effective use of spine radiosurgery. However, there is much less experience regarding the use of radiosurgery for the treatment of benign as opposed to malignant spine tumors. This study represents an evaluation of, and reporting on, the technical aspects of using a dedicated radiosurgery system for the treatment of benign spine tumors. Methods Forty-five consecutive benign spine tumors were treated using the Elekta Synergy S 6-MV linear accelerator with a beam modulator and cone-beam computed tomography (CBCT) image guidance technology for target localization. The study cohort included 16 men and 29 women, ranging in age from 23 to 88 years (mean age 52 years). There were 14 cervical, 12 thoracic, 14 lumbar, and 5 sacral tumors. Forty-one lesions (91%) were intradural. The most common histological types of tumor were schwannoma, neurofibroma, and meningioma. Indications for radiosurgery included primary treatment in 24 cases (53%) and treatment of recurrent or residual tumor after open resection in 21 cases (47%). Results No subacute or long-term spinal cord or cauda equina toxicity occurred during the follow-up period (median 32 months). The mean maximum dose received by the gross tumor volume (GTV) was 16 Gy (range 12–24 Gy) delivered in a single fraction in 39 cases. The mean lowest dose received to the GTV was 12 Gy (range 8–16 Gy). The GTV ranged from 0.37 to 94.5 cm3 (mean 13.7 cm3, median 5.9 cm3). In the majority of cases, a planning target volume expansion of 2 mm was employed (38 cases; 84%). The mean maximum point dose delivered to the spinal cord was 8.7 Gy (range 4–11.5 Gy); the mean volume of the spinal cord that received greater than 8 Gy was 0.9 cm3 (range 0.0–5.1 cm3); and the mean dose delivered to 0.1 cm3 of the spinal cord was 7.5 Gy (range 3–10.5 Gy). The mean maximum point dose delivered to the cauda equina was 10 Gy (range 0–13 Gy); the mean volume of the cauda equina that received greater than 8 Gy was 1.45 cm3 (range 0.0–10.6 cm3); and the mean dose delivered to 0.1 cm3 of the cauda equina was 8 Gy (range 0.5–11 Gy). Conclusions In this study the authors describe the contouring and prescribed dose techniques used in the treatment planning and delivery of radiosurgery for benign neoplasms of the spine using CBCT image guidance. This technique may serve as an important reference for the performance of radiosurgery when one believes it is clinically indicated as a treatment modality for a benign spine tumor that is associated with both a high safety profile and a strong positive clinical outcome.
- Published
- 2012
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