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Start Over Author "Caria, M. C." Publisher journal of rheumatology publishing co

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1. Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis.

Author

Ravelli A, Caria MC, Buratti S, Malattia C, Temporini F, and Martini A

Subjects
Child, Female, Humans, Syndrome, Antirheumatic Agents adverse effects, Arthritis, Juvenile drug therapy, Macrophage Activation, Macrophages drug effects, Methotrexate adverse effects
Abstract

Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS shortly after receiving methotrexate, suggesting that this drug can be regarded as a potential trigger of MAS in children with JIA.

Published
2001

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