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HD-OCT (high definition optical coherence tomography) is a promising non-invasive imaging tool with demonstrated utility in the in vivo accurate diagnosis of skin cancers but with slightly reduced applicability in other skin pathology, such as inflammatory or chronic connective tissue diseases. This technique can deliver high-resolution images of the skin layers similar with the histological aspect. The present study sought to detect and describe typical features regarding the pathological micro architectural pattern of localized scleroderma using HD- OCT and to see the utility in monitoring non-invasively the effects of first line treatments over relatively short period of time in this specific disease. [ABSTRACT FROM AUTHOR]

High definition optical coherence tomography (HD-OCT) is a non-invasive imaging technique, with significant relevance in different area, mainly ophthalmology. In recent years OCT has become a promising tool also for the in vivo evaluation and diagnosis of different skin diseases, especially skin cancers. HD OCT can be used as a reliable diagnosis method that provides useful information on the architecture of cutaneous layers and sometimes on cellular morphology in the epidermis and other structures of the skin. Our work brings new information about the value of HD-OCT in describing in vivo pattern of basal cell carcinoma, one of the most frequent non-melanocytic skin cancers, compared with histopathology and dermoscopy. [ABSTRACT FROM AUTHOR]