1. Hypothalamic sarcoidosis and hypopituitarism.
- Author
-
Jawadi MH, Hanson TJ, Schemmel JE, Beck P, and Katz FH
- Subjects
- 17-Hydroxycorticosteroids urine, Adolescent, Adrenocorticotropic Hormone, Adult, Female, Gonadotropin-Releasing Hormone, Growth Hormone blood, Humans, Hydrocortisone blood, Hydroxysteroids urine, Hypoglycemia chemically induced, Insulin, Luteinizing Hormone blood, Metyrapone, Middle Aged, Prolactin blood, Thyrotropin blood, Thyrotropin-Releasing Hormone, Vasopressins blood, Hypopituitarism metabolism, Hypothalamo-Hypophyseal System physiopathology, Sarcoidosis metabolism
- Abstract
4 patients with presumed pituitary hypothalamic sarcoidosis are described. 3 had histological diagnoses compatible with sarcoidosis and in the other this diagnosis was strongly suspected from chest X-rays. 2 patients presented with diabetes insipidus. ACTH reserve was diminished in 3 out of 4 and growth hormone reserve was diminished in the 3 who were tested. All 4 patients developed secondary amenorrhea. 3 patients had hypothalamic hypothyroidism. Prolactin dynamics were intact. Tomograms of the sella turcica in all 4 and computerized tomography of the hypothalamic area in 2 patients failed to reveal any abnormality.
- Published
- 1980
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