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1. Importance of the spleen for the immuno-inhibitory aciton of linoleic acid in mice.

Author

Mertin J, Meade CJ, Hunt R, and Sheena J

Subjects
Animals, Graft Rejection, Mice, Mice, Inbred A, Mice, Inbred C3H, Mice, Inbred CBA, Skin Transplantation, Splenectomy, Immunosuppression Therapy, Linoleic Acids immunology, Spleen immunology
Abstract

Certain immuno-inhibitory effects of a polyunsaturated fatty acid, linoleic acid (C18:2), no longer occur after splenectomy of young adult CBA mice. This observation suggest that the spleen is a major intermediary in the action of C18:2 on the lymphoreticular system. Pathways of this action remain to be elucidated. Possibilities include C18:2-stimulated suppressor cell generation in the spleen, or excess biosynthesis of immuno-inhibitory prostaglandins by splenic macrophages.

Published
1977
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