1. Clinical, diagnostic and therapeutic approaches to complications of brucellosis: an experience of 12 years.
- Author
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Mermut G, Ozgenç O, Avcı M, Olut AI, Oktem E, Genç VE, Arı A, and Coskuner SA
- Subjects
- Adolescent, Adult, Aged, Blood Sedimentation, Brucellosis diagnosis, C-Reactive Protein metabolism, Diagnosis, Differential, Doxycycline therapeutic use, Female, Gastrointestinal Diseases diagnosis, Gastrointestinal Diseases epidemiology, Gastrointestinal Diseases microbiology, Hematologic Diseases diagnosis, Hematologic Diseases epidemiology, Hematologic Diseases microbiology, Humans, Joint Diseases diagnosis, Joint Diseases epidemiology, Joint Diseases microbiology, Male, Middle Aged, Prevalence, Retrospective Studies, Rifampin therapeutic use, Streptomycin therapeutic use, Time Factors, Turkey, Young Adult, Anti-Bacterial Agents therapeutic use, Brucellosis complications, Brucellosis drug therapy, Gastrointestinal Diseases drug therapy, Hematologic Diseases drug therapy, Joint Diseases drug therapy
- Abstract
Objective: To describe the clinical presentations, laboratory findings, prevalence and pattern of complications and the response to treatment of brucellosis in a 12-year period in a Turkish research hospital., Materials and Methods: Between 1996 and 2008, 231 patients were diagnosed with brucellosis and treated in our clinic. Medical records of 189 of the 231 patients with at least one demonstrable complication of the disease were reviewed for anamnesis, diagnosis, complications, treatment and clinical outcomes., Results: The decreasing order of the complications was: hematological, 104 (55%); osteoarticular, 70 (37%); hepatobiliary, 59 (31%), and gastrointestinal, 23 (12%). The most common laboratory findings were anemia, lymphomonocytosis, elevated sedimentation rate and C-reactive protein, and elevated aminotransaminases., Conclusion: The hematological, osteoarticular and hepatobiliary manifestations were predominant. Bursitis, synovitis, glomerulonephritis, cutaneous lesion and deep vein thrombosis were the rare complications observed in our study. In clinical practice, brucellosis should be considered in the differential diagnosis in the presence of infrequent complications., (Copyright © 2011 S. Karger AG, Basel.)
- Published
- 2012
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