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2. Release of the vascular permeability factor in minimal change nephrotic syndrome is related to CD4+ lymphocytes.

Author

Tomizawa S, Nagasawa N, Maruyama K, Shimabukuro N, Arai H, and Kuroume T

Subjects
Adolescent, CD4-Positive T-Lymphocytes immunology, Child, Child, Preschool, Humans, Nephrotic Syndrome immunology, Nephrotic Syndrome pathology, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors, CD4-Positive T-Lymphocytes metabolism, Endothelial Growth Factors metabolism, Lymphokines metabolism, Nephrotic Syndrome metabolism
Published
1990
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3. Effect of supernatants derived from T lymphocyte culture in minimal change nephrotic syndrome on rat kidney capillaries.

Author

Maruyama K, Tomizawa S, Shimabukuro N, Fukuda T, Johshita T, and Kuroume T

Subjects
Animals, Anions metabolism, Basement Membrane metabolism, Binding Sites, Capillaries drug effects, Cells, Cultured, Child, Culture Media, Humans, Kidney Glomerulus metabolism, Kidney Glomerulus ultrastructure, Lymphokines urine, Male, Proteinuria chemically induced, Rats, Rats, Inbred Strains, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factors, Nephrosis, Lipoid metabolism, Renal Circulation, T-Lymphocytes metabolism
Abstract

The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.

Published
1989
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