1. Effects of captopril on the physical work capacity of normotensive patients with stable-effort angina pectoris.
- Author
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Strozzi C, Cocco G, Portaluppi F, Urso L, Alfiero R, Tasini MT, Montanari L, Al Yassini K, and Rizzo A
- Subjects
- Exercise Test, Female, Hemodynamics drug effects, Humans, Male, Middle Aged, Angina Pectoris drug therapy, Captopril therapeutic use, Physical Exertion drug effects
- Abstract
Twelve normotensive patients with coronary artery disease and stable effort-induced angina pectoris were selected: the antiischemic effect of captopril was studied. A maximal cycloergometer effort test was obtained before (base) and after administration of placebo or captopril (50 mg p.o.). The following parameters were measured: heart rate (HR), blood pressure (BP), maximal rate/pressure product (MRPP), maximal workload sustained, (MWS), maximal working time (MWT), and S-T depression at MRPP. The base and placebo were similar. Compared to them captopril augmented the MWT, increased the MWS, reduced S-T depression at MRPP, and decreased the number of patients with effort-induced angina pectoris. The antiischemic effect of captopril seems related both to its effect on HR and BP, and to a local enhancement of coronary blood flow.
- Published
- 1987
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