1. Incidence of Small Bowel Injury Induced by Low-Dose Aspirin: A Crossover Study Using Capsule Endoscopy in Healthy Volunteers.
- Author
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Endo, Hiroki, Hosono, Kunihiro, Inamori, Masahiko, Kato, Shingo, Nozaki, Yuichi, Yoneda, Kyoko, Akiyama, Tomoyuki, Fujita, Koji, Takahashi, Hirokazu, Yoneda, Masato, Abe, Yasunobu, Kirikoshi, Hiroyuki, Kobayashi, Noritoshi, Kubota, Kensuke, Saito, Satoru, Matsuhashi, Nobuyuki, and Nakajima, Atsushi
- Subjects
SMALL intestine ,TOXICITY testing ,ASPIRIN ,PHARMACEUTICAL encapsulation ,ENDOSCOPY ,PATHOLOGY - Abstract
Background and Aims: Small intestinal toxicity of low-dose aspirin remains unclear. The purpose of this capsule endoscopy study was to assess the incidence of small bowel injury in healthy volunteers treated with short-term low-dose aspirin. Methods: Healthy subjects were randomly assigned to receive low-dose aspirin for 14 days (Aspirin group) or no drugs for 14 days (Control group). The two treatment occasions were separated by a washout period of at least 4 weeks. All subjects underwent capsule endoscopy at the end of each treatment period. Results: After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023). The incidence of small bowel mucosal breaks in the Aspirin group was higher than that in the Control group, although the difference was not significant (30 vs. 0%; p = 0.210). Conclusions: This is the first pilot study using capsule endoscopy to report on the relation between small bowel injury and low-dose aspirin. Among the healthy subjects, the short-term administration of low-dose aspirin was associated with a mild mucosal inflammation of the small bowel. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2009
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