1. Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis.
- Author
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D'Arrigo, Graziella, Baggetta, Rossella, Tripepi, Giovanni, Galli, Francesco, and Bolignano, Davide
- Subjects
VITAMIN E ,HEMODIALYSIS ,BIOLOGICAL membranes ,ERYTHROCYTES ,OXIDATIVE stress ,META-analysis - Abstract
Introduction: Accruing evidence suggests that vitamin Ecoated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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