1. A Case-Control Study of ABCB1, ABCB6, and ABCG1 Polymorphisms and Schizophrenia in a Han Chinese Population.
- Author
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Ma, Gaini, Huang, Xiaoye, Bi, Yan, Xu, Fei, Niu, Weibo, Ren, Decheng, Sun, Qianqian, Guo, Zhenming, Yuan, Ruixue, Yuan, Fan, Wu, Xi, Yang, Fengping, Wang, Lu, Li, Weidong, He, Lin, Yu, Tao, Li, Xingwang, Liu, Jie, and He, Guang
- Subjects
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CASE-control method , *ATP-binding cassette transporters , *SCHIZOPHRENIA , *MENTAL illness , *CHINESE people - Abstract
Background: Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Mutations in the members of ABC transporters have been associated with psychiatric illnesses. Aims: In this study, we investigated whether 9 SNPs in ABCB1 (rs6946119, rs28401781, rs4148739, and rs3747802), ABCB6 (rs1109866, rs1109867, rs3731885, and rs3755047), and ABCG1 (rs182694) contribute to the risk of SCZ in a Han Chinese population. Methods: We conducted a case-control study in a Han Chinese population, involving 1,034 SCZ patients and 1,034 unrelated healthy controls to genotype 9 SNPs. Results: The analysis demonstrated that rs182694 of ABCG1 was significantly different between SCZ patients and controls as to allele (rs182694: p = 0.0070, χ2 = 7.27) and genotype frequencies (rs182694: p = 0.0013, χ2 = 13.35). Conclusions: Our findings support an association between ABCG1 polymorphism and SCZ in a Han Chinese population. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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