Itoh, Susumu, Yoshimura, Takuya, Tsujikawa, Kazutake, Yamada, Eitaro, Ishii, Tsuyoshi, Iemura, Osamu, Kameda, Yoichiro, Mimura, Tsutomu, and Kohama, Yasuhiro
26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D[sub 3] (ST-630) is a newly developed agent to maintain the levels of calcium and phosphorus in blood. Herein, we investigated the effect of this compound on the expression of vitamin-D-responsive genes in vitamin-D-deficient mice. ST-630 was more effective than 1,25-dihydroxyvitamin D[sub 3] [1,25(OH)[sub 2] D[sub 3] ] with respect to the induction of Cyp24 and calbindin-D[sub 9k] mRNAs in the kidney and in the small intestine. Moreover, the increase in mRNA levels of vitamin-D-responsive genes induced by ST-630 lasted longer than that induced by 1,25(OH)[sub 2] D[sub 3] . These results indicate that ST-630 was more effective in inducing Cyp24 and calbindin-D[sub 9k] gene expression than 1,25(OH)[sub 2] D[sub 3] when both compounds were injected into vitamin-D-deficient mice. [ABSTRACT FROM AUTHOR]