9 results on '"Susana Lopes"'
Search Results
2. A Rare Cause of Cholestasis Related to Polycystic Liver Disease
- Author
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Pedro Costa-Moreira, Susana Lopes, and Guilherme Macedo
- Subjects
polycystic liver disease ,vascular liver disease ,cholestasis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2021
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3. Evaluation of Small-Bowel Patency in Crohn’s Disease: Prospective Study with a Patency Capsule and Computed Tomography
- Author
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Marco Silva, Hélder Cardoso, Rui Cunha, Armando Peixoto, Rui Gaspar, Sara Gomes, Ana Luísa Santos, Susana Lopes, and Guilherme Macedo
- Subjects
Diagnosis and imaging ,Small-bowel endoscopy ,Capsule endoscopy ,Gastrointestinal radiology ,Inflammatory bowel disease ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and Purpose: Patency capsule (PC) examination is usually performed – previously to capsule endoscopy – to evaluate small-bowel patency in patients with established Crohn’s disease (CD). The reported PC retention rate is significantly higher than expected. Our aims were to assess small-bowel patency, to determine the precise location of the retained PC in patients with CD, and to determine the false positive rate of evaluation with a radiofrequency identification tag (RFIT) scanner. Methods: This is a prospective single-center study including CD patients with clinical indication for small-bowel capsule endoscopy. PillCam® PC examination was performed on all patients to assess small-bowel patency. On all patients with a positive identification of the PC using an RFIT scanner, 30 h after ingestion, an abdominal CT was performed in order to identify its precise location. Results: Fifty-four patients were included. The PC retention rate, according to evaluation with the RFIT scanner, was 20% (in 11 patients) 30 h after ingestion. These patients were then submitted to abdominal CT, which revealed that there was small-bowel retention in 5 cases (9%). Higher CRP levels, penetrating disease, and a history of abdominal surgery were associated with an increased risk of PC retention (p = 0.007, p = 0.011, and p = 0.033, respectively). On multivariate analysis, there was an independent association between small-bowel PC retention and CRP levels >5 mg/dL (OR = 15.5; p = 0.03). Discussion: The small-bowel PC retention rate (9%) was considerably lower than those found in previous reports. Our results show that, with this protocol, the false-positive cases of RFIT scans or plain abdominal X-rays may be avoided. This may contribute to more extensive application of capsule endoscopy without the risk of small-bowel retention.
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- 2019
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4. Mixed Adenoneuroendocrine Tumor of the Rectum in an Ulcerative Colitis Patient
- Author
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Rui Gaspar, João Santos-Antunes, Margarida Marques, Rodrigo Liberal, Daniel Melo, Pedro Pereira, Susana Lopes, and Guilherme Macedo
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Adenoneuroendocrine carcinoma ,Ulcerative colitis ,Endoscopic submucosal dissection ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Patients with inflammatory bowel disease present a higher risk of colorectal cancer, especially patients with a high degree of disease activity. Although rare, carcinoid tumors can also be associated with inflammatory bowel disease. Mixed adenoneuroendocrine tumor is defined as a neoplasm with dual differentiation (neuroendocrine and adenoma) with each component accounting for at least 30% of the tumor. We present a case of a mixed adenoneuroendocrine tumor in a patient with inflammatory bowel disease.
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- 2018
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5. Effect of Meal Ingestion on Liver Stiffness and Controlled Attenuation Parameter
- Author
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Marco Silva, Pedro Costa Moreira, Armando Peixoto, Ana Luísa Santos, Susana Lopes, Regina Gonçalves, Pedro Pereira, Hélder Cardoso, and Guilherme Macedo
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Liver disease ,Healthy volunteers ,Fibroscan ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and Aims: Despite the increasing use of noninvasive methods for the assessment of liver fibrosis and steatosis, the effect of fasting and food intake on these parameters is not yet clear. Our aims were to evaluate the effect of food intake on liver stiffness (LS) (measured by transient elastography) and controlled attenuation parameter (CAP) in patients with different degrees of liver disease and healthy volunteers, and secondarily, to assess possible factors associated with variations of LS and CAP. Methods: We performed a prospective single-center study including patients with liver disease and healthy volunteers. LS and CAP were evaluated using FibroScan® (Echosens, Paris, France), before (fasting ≥8 h) and 30 min after intake of a standardized breakfast. We used common cutoffs for LS: > 7 kPa for significant fibrosis (F2 to F4) and > 11 to 14 kPa (mean 12.5 kPa) for cirrhosis. Results: Fifty-nine (72%) patients with liver disease and 22 (28%) healthy volunteers were included. LS significantly increased 30 min after food intake (pre-meal 6.1 kPa [IQR: 4.7–9.8] vs. after-meal 6.8 kPa [IQR: 5.5–10.6]; p < 0.001). This difference was only significant in patients with chronic liver disease (p = 0.02) and not in healthy volunteers (p = 0.106). CAP values did not increase significantly after food intake. Gender, body mass index, mass of body fat, lean body mass, and percent of body fat were not related with significant variations of LS and CAP values after meal intake. Conclusions: Significant variations of LS were observed after ingestion of a standard meal, which may have consequences for patient management. CAP values were not significantly affected by food intake. Therefore, we consider that before the isolated evaluation of CAP, it is not necessary to perform any fasting period.
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- 2018
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6. CA 19-9 as a Marker of Survival and a Predictor of Metastization in Cholangiocarcinoma
- Author
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Rosa Coelho, Marco Silva, Eduardo Rodrigues-Pinto, Hélder Cardoso, Susana Lopes, Pedro Pereira, Filipe Vilas-Boas, João Santos-Antunes, José Costa-Maia, and Guilherme Macedo
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CA 19-9 antigen ,Cholangiocarcinoma ,Prognosis ,Tumor biomarkers ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Cholangiocarcinoma is the second most frequent primitive liver malignancy and is responsible for 3% of the malignant gastrointestinal neoplasms. The aims of this study were to determine the association of serum levels of CA 19-9 at diagnosis with other clinical data and serum liver function tests and to identify possible factors that influence the survival rates during follow-up. Methods: Retrospective observational study of 89 patients with a diagnosis of cholangiocarcinoma followed at the Department of Gastroenterology during 5 years. Statistical analyses were performed using SPSS version 20.0. Results: Patients were followed up for a median time of 127 days (IQR: 48-564), and the median age at diagnosis was 71.0 years (IQR: 62.0-77.5). The median survival rate was 14.0 months (IQR: 4.3-23.7), and the mortality rate was 79%. Patients with CA 19-9 levels ≥103 U/L had lower albumin levels and higher levels of alanine aminotransferase and γ-glutamyltransferase. CA 19-9 levels ≥103 U/L were associated with a higher probability of metastization (p = 0.001) and lower rates of treatment with curative intent (p = 0.024). In a multivariate analysis, CA 19-9 levels Conclusion: Predictive factors for overall survival were identified, namely presence of metastasis, surgery, and chemotherapy. CA 19-9 levels ≥103 U/L were predictive factors for survival and metastization.
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- 2017
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7. Preoperative Aerobic Capacity – Is There a Role for Routine Evaluation in Liver Transplantation?
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Patrícia Andrade and Susana Lopes
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Published
- 2015
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8. Sudden Respiratory Symptoms as Presentation of a Liver Mass
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Guilherme Macedo, Susana Lopes, João Pacheco, and Ana L. Santos
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Pediatrics ,medicine.medical_specialty ,business.industry ,dysphagia ,Gastroenterology ,hepatocellular carcinoma ,RC799-869 ,Diseases of the digestive system. Gastroenterology ,Liver mass ,Images in Gastroenterology and Hepatology ,endobronchial invasion ,endoscopic ultrasound ,medicine ,General Earth and Planetary Sciences ,Presentation (obstetrics) ,Respiratory system ,business ,General Environmental Science - Published
- 2021
9. Efeito da ingestão de uma refeição sobre a elastografia hepática transitória e o parâmetro de atenuação controlado
- Author
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Pedro Pereira, Hélder Cardoso, Guilherme Macedo, Armando Peixoto, Susana Rodrigues, Susana Lopes, Andreia Albuquerque, Regina Gonçalves, and Marco Silva
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medicine.medical_specialty ,Cirrhosis ,Chronic liver disease ,Gastroenterology ,03 medical and health sciences ,Liver disease ,0302 clinical medicine ,Liver stiffness ,Internal medicine ,medicine ,Ingestion ,lcsh:RC799-869 ,Healthy volunteers ,General Environmental Science ,Meal ,Voluntários saudáveis ,Hepatology ,Chemistry ,business.industry ,Attenuation ,Doença hepática ,medicine.disease ,Meal ingestion ,Endocrinology ,Fibroscan ,030220 oncology & carcinogenesis ,Lean body mass ,General Earth and Planetary Sciences ,030211 gastroenterology & hepatology ,Original Article ,lcsh:Diseases of the digestive system. Gastroenterology ,business ,Transient elastography ,Body mass index - Abstract
Background and Aims: Despite the increasing use of noninvasive methods for the assessment of liver fibrosis and steatosis, the effect of fasting and food intake on these parameters is not yet clear. Our aims were to evaluate the effect of food intake on liver stiffness (LS) (measured by transient elastography) and controlled attenuation parameter (CAP) in patients with different degrees of liver disease and healthyvolunteers, and secondarily, to assess possible factors associated with variations of LS and CAP. Methods: We performed a prospective single-center study including patients with liver disease and healthy volunteers. LS and CAP were evaluated using FibroScan® (Echosens, Paris, France), before (fasting ≥8 h) and 30 min after intake of a standardized breakfast. We used common cutoffs for LS: > 7 kPa for significant fibrosis (F2 to F4) and > 11 to 14 kPa (mean 12.5 kPa) for cirrhosis. Results: Fifty-nine (72%) patients with liver disease and 22 (28%) healthy volunteers were included. LS significantly increased 30 min after food intake (pre-meal 6.1 kPa [IQR: 4.7-9.8] vs. after-meal 6.8 kPa [IQR: 5.5-10.6]; p < 0.001). This difference was only significant in patients with chronic liver disease (p = 0.02) and not in healthy volunteers (p = 0.106). CAP values did not increase significantly after food intake. Gender, body mass index, mass of body fat, lean body mass, and percent of body fat were not related with significant variations of LS and CAP values after meal intake. Conclusions: Significant variations of LS were observed after ingestion of a standard meal, which may have consequences for patient management. CAP values were not significantly affected by food intake. Therefore, we consider that before the isolated evaluation of CAP, it is not necessary to perform any fasting period. Introdução e Objetivos: Apesar do uso crescente de métodos não invasivos para a avaliação da fibrose hepática e da esteatose, ainda não está claro o efeito do jejum e da ingestão alimentar na determinação destes parâmetros. Os nossos objetivos foram avaliar o efeito da ingestão de alimentos sobre a rigidez hepática (LS) (medida por elastografia transitória) e o parâmetro de atenuação controlada (CAP) em doentes com diferentes graus de doença hepática e voluntários saudáveis e, secundariamente, avaliar possíveis fatores associados às variações de LS e CAP. Métodos: Realizámos um estudo prospetivo, num único centro, incluindo doentes com doença hepática crónica e voluntários saudáveis. A LS e o CAP foram determinados com a utilização de FibroScan®, antes (jejum ≥8 h) e 30 minutos após a ingestão de um pequeno-almoço padronizado. Foram usados pontos de corte comuns para a elastografia: > 7 kPa para fibrose significativa (F2 a F4) e > 11-14 kPa (média 12.5 kPa) para cirrose. Resultados: Cinquenta e nove (72%) doentes com doença hepática crónica e 22 (28%) voluntários saudáveis foram incluídos. A LS aumentou significativamente 30 minutos após a ingestão de alimentos (pré-refeição 6.1 kPa [IQR: 4.7-9.8] versus após a refeição 6.8 kPa [IQR: 5.5-10.6], p < 0.001). Essa diferença foi significativa em doentes com doença hepática crónica (p = 0.02) mas não nos voluntários saudáveis (p = 0.106). Os valores da CAP não variaram significativamente após a ingestão de alimentos. O género, o IMC, a massa de gordura corporal, a massa corporal magra e a percentagem de gordura corporal não se associaram a variações significativas dos valores de LS e CAP após a ingestão da refeição. Conclusões: Verificaram-se variações significativas da LS após a ingestão de uma refeição padrão, o que pode ter consequências na avaliação dos doentes. Os valores da CAP não foram significativamente afetados pela ingestão de alimentos. Por isso, consideramos que perante a avaliação isolada de CAP não é necessário a realização de qualquer período de jejum.
- Published
- 2018
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